{"doi":"10.1016/j.jns.2017.04.030","title":"Pattern of care and outcome in elderly patients with glioblastoma: Data in 151 patients from 3 Lombardia Hospitals","abstract":null,"journal":"Journal of the Neurological Sciences","year":2017,"id":638379,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1658008,"name":"Francesca Imbesi","orcid":null,"position":1,"is_corresponding":false},{"id":1658010,"name":"Antonio Silvani","orcid":null,"position":2,"is_corresponding":false},{"id":1658012,"name":"Gianluca Grimod","orcid":null,"position":3,"is_corresponding":false},{"id":1658014,"name":"Valentina Prone","orcid":null,"position":4,"is_corresponding":false},{"id":1658015,"name":"Paola Gaviani","orcid":null,"position":5,"is_corresponding":false},{"id":1658016,"name":"Antonio Ardizzoia","orcid":null,"position":6,"is_corresponding":false},{"id":1658017,"name":"Ida Milanesi","orcid":null,"position":7,"is_corresponding":false},{"id":1658019,"name":"Virginia Arienti","orcid":null,"position":8,"is_corresponding":false},{"id":1658020,"name":"Elio Agostoni","orcid":null,"position":9,"is_corresponding":false},{"id":1658021,"name":"Francesco Di Meco","orcid":null,"position":10,"is_corresponding":false},{"id":1658022,"name":"Andrea Salmaggi","orcid":null,"position":11,"is_corresponding":false},{"id":1658006,"name":"Andrea Rigamonti","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pattern of care and outcome in elderly patients with glioblastoma: Data in 151 patients from 3 Lombardia Hospitals","abstract":"The appropriate treatment approach for elderly patients with glioblastoma multiforme (GBM) is unclear, although different studies suggest survival benefit in fit patients treated with radiotherapy and chemiotherapy after surgery. We performed a retrospective analysis of 151 patients older than 65years with GBM treated in 3 Lombardia Hospitals. In univariate regression analysis higher KPS (p=0.02), macroscopical total resection (p<0.003), radiotherapy (p<0.0001), chemotherapy (p<0.0001) and second line chemotheraphy (p=0.02) were of positive prognostic value. On the contrary older age (>70years), presence of seizure at onset and additional resection after tumor recurrence did not influence OS. Multivariate analysis revealed radiotherapy (HR 0.2 p<0.0001) and extent of surgery (HR 0.3, p=0,0063) as positive independent prognostic factors. Patients receiving radio-chemiotherapy displayed more treatment-related toxicities with a slightly prolonged OS versus those receiving hypofractionated radiotherapy. With the limits of a retrospective study, our data suggest that in elderly fit patients extensive surgery should be considered, moreover adjuvant treatments led to an increase in OS. Randomized controlled study are needed to develop treatment guidelines for elderly GBM patients and to assess whether the combination of post-surgical radio and chemiotherapy may be superior to hypofractionated radiotherapy and chemiotherapy in fit patients.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28566172","pmcid":null,"openalex_id":"https://openalex.org/W2606371609","authors":[],"funders":[],"total_grants":0,"fwci":1.3684,"citation_percentile":0.80395944,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022510X17302642?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022510X17302642?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jns.2017.04.030","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28566172","host_type":"repository"}],"fields_of_study":["Glioma Diagnosis and Treatment","Meningioma and schwannoma management","Brain Metastases and Treatment","Aged","Aged, 80 and over","Brain Neoplasms","Combined Modality Therapy","Female","Glioblastoma","Humans","Kaplan-Meier Estimate","Male","Multivariate Analysis","Neurosurgical Procedures","Proportional Hazards Models","Regression Analysis","Retrospective Studies","Treatment Outcome"],"mesh_terms":["Aged","Aged, 80 and over","Brain Neoplasms","Combined Modality Therapy","Female","Glioblastoma","Humans","Male","Regression Analysis","Retrospective Studies","Multivariate Analysis","Proportional Hazards Models","Treatment Outcome","Neurosurgical Procedures","Kaplan-Meier Estimate"],"keywords":["Medicine","Radiation therapy","Glioblastoma","Retrospective cohort study","Multivariate analysis","Univariate analysis","Internal medicine","Chemotherapy","Oncology","Adjuvant radiotherapy","Adjuvant","Surgery","Survival","Elderly","Extent Of Resection","Radiotherapy,"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T20:35:01.681363Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}