{"doi":"10.1016/j.jnrt.2025.100186","title":"X-ray-based ultra-high dose rate FLASH radiotherapy mitigates acute radiation-induced hippocampal injury and inflammation","abstract":null,"journal":"Journal of Neurorestoratology","year":2025,"id":614463,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1287611,"name":"Jiayu Liu","orcid":"0000-0002-4172-8802","position":1,"is_corresponding":false},{"id":1583383,"name":"Bingxian Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1583384,"name":"Hanbo Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1583385,"name":"Shengqiang Xie","orcid":null,"position":4,"is_corresponding":false},{"id":706457,"name":"Yiyuan Zhang","orcid":"0000-0002-7150-1342","position":5,"is_corresponding":false},{"id":1583386,"name":"Xianhong Liu","orcid":null,"position":6,"is_corresponding":false},{"id":1207040,"name":"Jianxin Wang","orcid":"0000-0002-0998-4996","position":7,"is_corresponding":false},{"id":1583387,"name":"Dai Wu","orcid":null,"position":8,"is_corresponding":false},{"id":1583388,"name":"Lehui Du","orcid":null,"position":9,"is_corresponding":false},{"id":1583389,"name":"Baolin Qu","orcid":null,"position":10,"is_corresponding":false},{"id":571403,"name":"Gang Cheng","orcid":"0000-0002-9165-6181","position":11,"is_corresponding":false},{"id":124036,"name":"Jianning Zhang","orcid":"0000-0003-1943-7045","position":12,"is_corresponding":false},{"id":1583382,"name":"Renke He","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"X-ray-based ultra-high dose rate FLASH radiotherapy mitigates acute radiation-induced hippocampal injury and inflammation","abstract":"To compare neural damage induced by ultra-high dose rate FLASH radiotherapy (FLASH-RT) with that induced by conventional dose rate radiotherapy (CONV-RT) in healthy mice. Eighty adult male C57BL/6J mice were divided into five groups: Sham, CONV-RT10Gy, CONV-RT20Gy, FLASH-RT10Gy, and FLASH-RT20Gy. Three days post-irradiation, morphological changes in neurons within the dentate gyrus (DG), CA1, and CA3 were observed using hematoxylin and eosin and Nissl staining. The malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), catalase (CAT), and hydroxyl radical (OH − ) levels were measured using assay kits. Quantitative reverse transcription PCR was used to assess interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), and tumor necrosis factor (TNF)-α mRNA expression levels in hippocampus. Immunofluorescence was employed to observe microglial activation in the DG. Compared with Sham, CONV-RT10Gy and CONV-RT20Gy exhibited disorganized neuronal arrangements and blurred nucleoli in the DG; the number of Nissl body was reduced, but FLASH-RT10Gy and FLASH-RT20Gy alleviated these abnormalities. Moreover, FLASH-RT20Gy mitigated the upregulation of MDA and downregulation of GSH, GSH-PX, SOD, CAT, and OH − levels in the hippocampus of mice subjected to CONV-RT20Gy. Additionally, FLASH-RT20Gy attenuated the upregulation of IL-1β, IL-6, iNOS, and TNF-α mRNA levels in hippocampus of mice subjected to CONV-RT20Gy and diminished microglial activation in the DG. FLASH-RT mitigate the structural and functional disruptions in hippocampal neurons induced by CONV-RT and alleviate oxidative stress and inflammation in hippocampal tissue by reducing microglial activation.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23304386","pmcid":null,"openalex_id":"https://openalex.org/W4406572695","authors":[],"funders":[],"total_grants":0,"fwci":2.3394,"citation_percentile":0.86327433,"influential_citations":0,"citation_trend":[{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jnrt.2025.100186","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jnrt.2025.100186","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2324242625000087?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2324242625000087?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":["Radiation Therapy and Dosimetry","Effects of Radiation Exposure","Anesthesia and Neurotoxicity Research"],"mesh_terms":[],"keywords":["Flash (photography)","Radiation therapy","Inflammation","Hippocampal formation","Medicine","Radiation","X-ray","Radiation dose","Dose rate","Radiology","Nuclear medicine","Internal medicine","Medical physics","Physics","Optics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T13:35:49.159951Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}