{"doi":"10.1016/j.jneuroim.2016.09.009","title":"Osteopontin directly modulates cytokine expression of primary microglia and increases their survival","abstract":null,"journal":"Journal of Neuroimmunology","year":2016,"id":634073,"datarank":0.6010999777848708,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.0,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644332,"name":"Sabine Ulrike Vay","orcid":null,"position":1,"is_corresponding":false},{"id":349221,"name":"Lea Jessica Flitsch","orcid":null,"position":2,"is_corresponding":false},{"id":1644334,"name":"Gereon Rudolf Fink","orcid":null,"position":3,"is_corresponding":false},{"id":1644337,"name":"Michael Schroeter","orcid":null,"position":4,"is_corresponding":false},{"id":1365180,"name":"Maria Adele Rueger","orcid":"0000-0001-8036-395X","position":5,"is_corresponding":false},{"id":1644330,"name":"Monika Rabenstein","orcid":"0000-0002-6183-6253","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Osteopontin directly modulates cytokine expression of primary microglia and increases their survival","abstract":"Osteopontin (OPN) is constitutively expressed in the brain and upregulated during neuroinflammation, e.g., focal cerebral ischemia. In OPN-deficient mice, microglia are deregulated after ischemia, but specific OPN-effects on microglia remain elusive. Primary microglia were cultured in the presence or absence of OPN. The survival of microglia under stress conditions was dose-dependently increased by OPN. Lipopolysaccharides (LPS)-induced release of nitric oxide (NO), TNF-α, and IL-6, as well as expression of inducible Nitric Oxide Synthase (iNOS), were attenuated by OPN. Data suggest that OPN modulates microglia function by shifting their inflammatory profile towards a neutral anti-inflammatory phenotype.","is_dataset_classified":null,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27725111","pmcid":null,"openalex_id":"https://openalex.org/W2519262725","authors":[],"funders":[{"funder_name":"Marga und Walter Boll-Stiftung","grant_id":"#210-10-15","title":null},{"funder_name":"Köln Fortune Program/Faculty of Medicine, University of Cologne, Germany","grant_id":"#190/2014","title":null},{"funder_name":"Köln Fortune Program/Faculty of Medicine, University of Cologne, Germany","grant_id":"#339/2015","title":null}],"total_grants":3,"fwci":2.9988,"citation_percentile":0.90638657,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":6},{"year":2019,"count":2},{"year":2020,"count":15},{"year":2021,"count":12},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0165572816302727?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165572816302727?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jneuroim.2016.09.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27725111","host_type":"repository"}],"fields_of_study":["Bone and Dental Protein Studies","Bone Metabolism and Diseases","Neuroinflammation and Neurodegeneration Mechanisms","Animals","Animals, Newborn","Cell Survival","Cells, Cultured","Cytokines","Dose-Response Relationship, Drug","Gene Expression","Microglia","Osteopontin","Rats"],"mesh_terms":["Animals","Animals, Newborn","Cell Survival","Cells, Cultured","Dose-Response Relationship, Drug","Gene Expression","Cytokines","Microglia","Rats","Osteopontin"],"keywords":["Microglia","Osteopontin","Neuroinflammation","Nitric oxide","Nitric oxide synthase","Downregulation and upregulation","Cytokine","Tumor necrosis factor alpha","Chemistry","Cell biology","Inflammation","Immunology","Biology","Endocrinology","Biochemistry","Regeneration","Neural stem cells","focal cerebral ischemia","neuroprotection"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:06:22.970499Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}