{"doi":"10.1016/j.jneumeth.2025.110671","title":"Feature library for behavioural characterization of early and late seizures in an experimental model of post-traumatic epilepsy","abstract":null,"journal":"Journal of Neuroscience Methods","year":2026,"id":623494,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":65608,"name":"Asla Pitkänen","orcid":"0000-0002-8163-5416","position":1,"is_corresponding":false},{"id":855798,"name":"Pedro Andrade","orcid":"0000-0003-2540-2471","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Feature library for behavioural characterization of early and late seizures in an experimental model of post-traumatic epilepsy","abstract":"BACKGROUND: To generate a behavioral feature library for a more granular description of seizure semiology in rats with traumatic brain injury (TBI). To compare the new approach to the Racine score. NEW METHOD: A library of 59 seizure-related behavioral features was generated by annotating 329 seizures in 31 rats with TBI, which were monitored using high-resolution video-electroencephalogram. Of the 329 seizures, 149 were early, 85 post-electrode implantation (6th post-injury month), and 95 late seizures (7th post-injury month). Of the 59 behavioral features, 3 were pre-ictal, 43 ictal, and 13 post-ictal. Of the 43 ictal features, 7 related to consciousness, 5 to mouth and whiskers, 2 to eyes, 7 to head, 2 to ears, 6 to paws, 12 to body and tail, 2 to autonomic function, and 1 to wet-dog shakes. RESULTS: Early, post-implantation, and late seizures showed different behavioral phenotypes (p < 0.001). The number of behavioral features in post-electrode implantation and late seizures was greater than that in early seizures (p < 0.05). Behavioral features did not reliably differentiate transitions from pre-ictal to ictal or from ictal to post-ictal phases. COMPARISON WITH EXISTING METHODS: Ninety-one percent of early, 45 % of post-electrode implantation, and 18 % of late seizures with a Racine score of 0 showed up to 6-7 ictal-related behaviors. CONCLUSIONS: The Proposed feature list can be applied for the harmonization of data analysis and reporting, and training of video-based seizure detection algorithms to speed up non-invasive, affordable epilepsy diagnosis and assessment of treatment effects in TBI models.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41490663","pmcid":null,"openalex_id":"https://openalex.org/W7118065065","authors":[],"funders":[{"funder_name":"Research Council for Biosciences and Environment","grant_id":"348071","title":null},{"funder_name":"Sigrid Jusélius Foundation","grant_id":"250183","title":null},{"funder_name":"National Institute of Neurological Disorders and Stroke","grant_id":"U54NS100064","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"P20 NS080181","title":null},{"funder_name":"National Institutes of Health","grant_id":"","title":null},{"funder_name":"Research Council of Finland","grant_id":"","title":null}],"total_grants":6,"fwci":8.308,"citation_percentile":0.93205778,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jneumeth.2025.110671","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jneumeth.2025.110671","host_type":"HYBRID"},{"url":"https://doi.org/10.1016/j.jneumeth.2025.110671","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165027025003152?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165027025003152?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41490663","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13384811/","host_type":"repository"}],"fields_of_study":["EEG and Brain-Computer Interfaces","Epilepsy research and treatment","Emotion and Mood Recognition","Medicine","Animals","Epilepsy, Post-Traumatic","Disease Models, Animal","Male","Electroencephalography","Behavior, Animal","Rats","Rats, Sprague-Dawley","Video Recording","Brain Injuries, Traumatic","Seizures","Time Factors"],"mesh_terms":["Brain Injuries, Traumatic","Animals","Behavior, Animal","Disease Models, Animal","Electroencephalography","Epilepsy, Post-Traumatic","Male","Seizures","Time Factors","Video Recording","Rats, Sprague-Dawley","Rats"],"keywords":["Epilepsy","Feature (linguistics)","Pattern recognition (psychology)","Feature extraction","Training set","Electroencephalography","Traumatic brain injury","Common Data Elements","Semiology","Lateral Fluid-percussion","High Resolution Video-electroencephalogram"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T00:07:59.222141Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}