{"doi":"10.1016/j.jneumeth.2006.07.026","title":"Comparison between one- and two-hemorrhage models of cerebral vasospasm in rabbits","abstract":null,"journal":"Journal of Neuroscience Methods","year":2007,"id":684132,"datarank":0.5837730447165941,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.0,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1787262,"name":"Ji-Xin Shi","orcid":null,"position":1,"is_corresponding":false},{"id":1787263,"name":"Jia-Quan Zhu","orcid":null,"position":2,"is_corresponding":false},{"id":1787264,"name":"Chun-Hua Hang","orcid":null,"position":3,"is_corresponding":false},{"id":473563,"name":"Lei Mao","orcid":"0000-0002-8857-621X","position":4,"is_corresponding":false},{"id":1515537,"name":"Ke-Fei Chen","orcid":null,"position":5,"is_corresponding":false},{"id":1787265,"name":"Hong-Xia Yin","orcid":null,"position":6,"is_corresponding":false},{"id":1787261,"name":"Meng-Liang Zhou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison between one- and two-hemorrhage models of cerebral vasospasm in rabbits","abstract":"Injection of blood into the cisterna magna is one of the most frequently used methods to produce subarachnoid hemorrhage (SAH) models in animals. Although the two-hemorrhage model of vasospasm is frequently used in canine and rat models, most studies with rabbits only use the one-hemorrhage model. In the present study, we accomplished a side-by-side comparison between one- and two-hemorrhage models in rabbits. A total of 38 rabbits were randomly divided into three groups, i.e. control group (n = 5), one (n = 15)- and two (n = 18)-hemorrhage model groups. The degree of cerebral vasospasm, the time course of cerebral vasospasm, the clinical behavior, and the residual amount of subarachnoid blood clots were measured on days 3, 5 and 7 after the establishment of the models. Compared with one-hemorrhage model, the time course of vasospasm in the two-hemorrhage model was more coincident with that observed in humans, produced more severe vasospasm after SAH, and had an acceptable low mortality. In conclusion, the two-hemorrhage model in rabbits is more appropriate than the one-hemorrhage model for the research on SAH or cerebral vasospasm, and thus can be used for the investigation of the mechanisms of and therapeutic approaches for cerebral vasospasm.","is_dataset_classified":null,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16942802","pmcid":null,"openalex_id":"https://openalex.org/W2010013803","authors":[],"funders":[],"total_grants":0,"fwci":1.9043,"citation_percentile":0.85058481,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":4},{"year":2014,"count":6},{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2022,"count":2},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0165027006003402?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165027006003402?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jneumeth.2006.07.026","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16942802","host_type":"repository"}],"fields_of_study":["Intracranial Aneurysms: Treatment and Complications","Traumatic Brain Injury and Neurovascular Disturbances","Vascular Malformations Diagnosis and Treatment"],"mesh_terms":["Animals","Basilar Artery","Disease Models, Animal","Rabbits","Severity of Illness Index","Subarachnoid Hemorrhage","Survival Rate","Vasospasm, Intracranial"],"keywords":["Subarachnoid hemorrhage","Cerebral vasospasm","Cisterna magna","Medicine","Vasospasm","Anesthesia","Animal model","Internal medicine","Cerebrospinal fluid"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T13:22:55.194534Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}