{"doi":"10.1016/j.jmro.2025.100205","title":"Hyperpolarized [1-¹³C] pyruvate MRSI reveals a diet-dependent metabolic shift in ZSF1 rats","abstract":"We evaluated altered cardiac metabolism in Zucker Spontaneously Hypertensive Fatty (ZSF1) rats fed an isocaloric high-fat diet versus normal chow using hyperpolarized (HP) [1- 13 C]pyruvate MR spectroscopic imaging (MRSI). This technique exploits remarkable signal enhancement to track the metabolic fate of injected HP [1- 13 C]pyruvate in vivo , allowing a simultaneous assessment in multiple metabolic pathways. The conversion of [1- 13 C]pyruvate to [1- 13 C]lactate (Lac) reflects anaerobic glycolysis activity, while the detection of 13 C-bicarbonate (Bic) indicates glucose oxidation . Our findings show that ZSF1 rats fed a high-fat diet exhibit a greater reliance on anaerobic glycolysis relative to glucose oxidation, and this metabolic shift can be detected in vivo in real time. This study demonstrates the feasibility of HP [1- 13 C]pyruvate MRSI for assessing diet-dependent metabolic shifts in the myocardium of ZSF1 obese rats, a widely used preclinical model for heart failure with preserved ejection fraction (HFpEF).","journal":"Journal of Magnetic Resonance Open","year":2025,"id":569603,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.962,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":260474,"name":"Salva R. Yurista","orcid":"0000-0001-9126-739X","position":1,"is_corresponding":false},{"id":1475125,"name":"Sophia M Mirrione","orcid":null,"position":2,"is_corresponding":false},{"id":1028166,"name":"David Guarin","orcid":"0000-0002-1388-0559","position":3,"is_corresponding":false},{"id":1475126,"name":"Samuel R Calos","orcid":null,"position":4,"is_corresponding":false},{"id":341596,"name":"Ivan Luptak","orcid":"0000-0001-7498-7694","position":5,"is_corresponding":false},{"id":235432,"name":"Atsushi Takahashi","orcid":"0000-0002-5182-4320","position":6,"is_corresponding":false},{"id":30816,"name":"W. H. Wilson Tang","orcid":"0000-0002-8335-735X","position":7,"is_corresponding":false},{"id":271225,"name":"Yoshiko Iwamoto","orcid":"0000-0002-3723-1043","position":8,"is_corresponding":false},{"id":1217688,"name":"Christopher T. Nguyen","orcid":null,"position":9,"is_corresponding":false},{"id":730305,"name":"Yi‐Fen Yen","orcid":"0000-0001-9986-5327","position":10,"is_corresponding":false},{"id":1474781,"name":"Karen Dos Santos","orcid":"0000-0003-1233-8490","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:57:03.510013Z","pmid":"40689081","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}