{"doi":"10.1016/j.jmr.2025.107890","title":"Strong field gradients enable NMR-based diffusion measurements for K+, Mg2+, Cl−, and SO42− ions in biomolecular solutions","abstract":"ions in biomolecular solutions can be measured accurately and precisely through use of appropriately designed high-field NMR probe hardware that can generate strong field gradients >1000 G/cm. The NMR-based diffusion coefficients measured at 17.6 T for these ions in the absence of biomolecules agreed well with conductivity-based values in the literature. This consistency supports that ion diffusion along the magnetic field is unaffected by the Lorentz force acting on the ions, as previously predicted. Our data on ion diffusion in solutions of proteins and DNA illuminate the effect of electrostatic interactions on the apparent diffusion coefficients of ions. Thus, high-field NMR probe hardware that can generate strong field gradients opens a new avenue to characterize the dynamic behavior of various ions around biomolecules and their effect on biomolecular electrostatics.","journal":"Journal of Magnetic Resonance","year":2025,"id":519478,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1387860,"name":"Daniel Arcos","orcid":"0000-0002-5367-7272","position":1,"is_corresponding":false},{"id":781576,"name":"F. David Doty","orcid":"0000-0003-2608-8170","position":2,"is_corresponding":false},{"id":405162,"name":"B. Montgomery Pettitt","orcid":"0000-0003-4902-3046","position":3,"is_corresponding":false},{"id":492727,"name":"Junji Iwahara","orcid":"0000-0003-4732-2173","position":4,"is_corresponding":false},{"id":923711,"name":"Tianzhi Wang","orcid":"0000-0001-6838-0757","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:49:18.751199Z","pmid":"40339514","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}