{"doi":"10.1016/j.jmii.2023.07.014","title":"Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients","abstract":"OBJECTIVES: To assess associations between disease severity in index TB patients and QuantiFERON-TB Gold Plus (QFT-Plus) results in contacts, and predictors for QFT-Plus conversion in contacts over 6-12 months. METHODS: TB patients (n = 295) and the contacts (n = 1051) were enrolled during 2018-2021 with QFT-Plus performed at baseline and months 6 and 12. A strong CD8 response was defined as TB2 interferon gamma (IFN-γ) response minus TB1 >0.6 IU/ml and stringent conversion as change from QFT-plus negative to high-positive QFT-Plus (TB1 or TB2 IFN-γ responses >0.7 IU/ml). RESULTS: Contacts with index TB patients with sputum smear >1+ was associated with positive QFT-Plus compared to those without (p < 0.001). Contacts with index TB patients with bilateral lung disease were more likely to have strong CD8 responses than those without (p = 0.038). QFT-Plus stringent conversion occurred in 9.7% of contacts over 6-12 months. A TB1 IFN-γ response ≥0.03 IU/ml combined with a TB2 ≥0.06 IU/ml was predictive of a 19-fold increased risk for QFT-Plus stringent conversion in contacts (odd ratio 19.565 [8.484-45.116], p < 0.001). CONCLUSION: Bacterial burden and bilateral lung disease of index TB patients were associated with positive QFT-Plus and strong CD8 responses in contacts. TB1 and TB2 IFN-γ responses were synergistically predictive of stringent conversion in contacts.","journal":"Journal of Microbiology Immunology and Infection","year":2023,"id":367249,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7833,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":707404,"name":"Donald G. Catanzaro","orcid":"0000-0003-1760-0574","position":1,"is_corresponding":false},{"id":537715,"name":"Marva Seifert","orcid":"0000-0002-7554-6396","position":2,"is_corresponding":false},{"id":786908,"name":"Rehan R. Syed","orcid":"0000-0001-8898-7388","position":3,"is_corresponding":false},{"id":800014,"name":"Naomi Hillery","orcid":"0000-0002-6471-0306","position":4,"is_corresponding":false},{"id":926985,"name":"Mei‐Lin Ho","orcid":"0000-0001-6315-1832","position":5,"is_corresponding":false},{"id":399672,"name":"Valeriu Crudu","orcid":"0000-0001-5059-8002","position":6,"is_corresponding":false},{"id":1124399,"name":"Elena Tudor","orcid":"0000-0002-8068-5972","position":7,"is_corresponding":false},{"id":399668,"name":"Nelly Ciobanu","orcid":"0000-0003-1032-0617","position":8,"is_corresponding":false},{"id":861627,"name":"Alexandru Codreanu","orcid":"0000-0002-7331-8138","position":9,"is_corresponding":false},{"id":676707,"name":"Antonino Catanzaro","orcid":"0000-0002-1237-1744","position":10,"is_corresponding":false},{"id":301785,"name":"Timothy C. Rodwell","orcid":"0000-0003-2779-3197","position":11,"is_corresponding":false},{"id":926984,"name":"Sheng‐Wei Pan","orcid":"0000-0002-7400-6996","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T01:15:12.215513Z","pmid":"37580184","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}