{"doi":"10.1016/j.jmb.2021.166945","title":"Platforms for Personalized Polytherapeutics Discovery in COVID-19","abstract":"The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems.","journal":"Journal of Molecular Biology","year":2021,"id":207355,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":437045,"name":"Chidinma Onweni","orcid":null,"position":1,"is_corresponding":false},{"id":793462,"name":"Victoria Zambito","orcid":null,"position":2,"is_corresponding":false},{"id":248042,"name":"DeLisa Fairweather","orcid":"0000-0003-3093-1810","position":3,"is_corresponding":false},{"id":793463,"name":"Kathryn McCormick","orcid":null,"position":4,"is_corresponding":false},{"id":235626,"name":"Hideki Ebihara","orcid":"0000-0002-2576-9735","position":5,"is_corresponding":false},{"id":274153,"name":"Thomas R. Caulfield","orcid":"0000-0002-1055-3069","position":6,"is_corresponding":false},{"id":241270,"name":"Yu Shrike Zhang","orcid":"0000-0002-0045-0808","position":7,"is_corresponding":false},{"id":645981,"name":"William D. Freeman","orcid":"0000-0003-2326-0633","position":8,"is_corresponding":false},{"id":792875,"name":"Christopher E. Hopkins","orcid":"0000-0002-6981-6329","position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":null,"created_at":"2026-07-18T23:51:49.715594Z","pmid":"33753053","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}