{"doi":"10.1016/j.jmb.2012.05.013","title":"NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway","abstract":null,"journal":"Journal of Molecular Biology","year":2012,"id":665695,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1738327,"name":"Yann Thomas","orcid":null,"position":1,"is_corresponding":false},{"id":569797,"name":"Thimo Kurz","orcid":"0000-0003-0700-6993","position":2,"is_corresponding":false},{"id":1738326,"name":"Roland Hjerpe","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway","abstract":"Ubiquitin and ubiquitin-like proteins use unique E1, E2, and E3 enzymes for conjugation to their substrates. We and others have recently reported that increases in the relative concentration of the ubiquitin-like protein NEDD8 over ubiquitin lead to activation of NEDD8 by the ubiquitin E1 enzyme. We now show that this results in erroneous conjugation of NEDD8 to ubiquitin substrates, such as p53, Caspase 7, and Hif1α, demonstrating that overexpression of NEDD8 is not appropriate for identification of substrates of the NEDD8 pathway.","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22608973","pmcid":null,"openalex_id":"https://openalex.org/W1992831066","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"243019","title":"Regulation and Function of Cullin-Ring E3 ubiquitin ligases and the Nedd8 ubiquitin-like protein modification system"}],"total_grants":1,"fwci":2.4561,"citation_percentile":0.89309324,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":9},{"year":2014,"count":3},{"year":2015,"count":6},{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":1},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0022283612003981/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0022283612003981/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022283612003981?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022283612003981?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jmb.2012.05.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22608973","host_type":"repository"},{"url":"https://discovery.dundee.ac.uk/en/publications/e46eb022-03db-42ed-b795-ea82cf8911c5","host_type":"repository"},{"url":"http://eprints.gla.ac.uk/138906/1/138906.pdf","host_type":"journal"},{"url":"http://dx.doi.org/10.1016/j.jmb.2012.05.013","host_type":""},{"url":"https://eprints.gla.ac.uk/138906/1/138906.pdf","host_type":""},{"url":"https://dx.doi.org/10.1016/j.jmb.2012.05.013","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.jmb.2012.05.013","host_type":""}],"fields_of_study":["Ubiquitin and proteasome pathways","Cancer-related gene regulation","Peptidase Inhibition and Analysis","0301 basic medicine","0303 health sciences","03 medical and health sciences","Caspase 7","Cells, Cultured","Cyclopentanes","Gene Expression Regulation","Humans","Hypoxia-Inducible Factor 1, alpha Subunit","NEDD8 Protein","Pyrimidines","Tumor Suppressor Protein p53","Ubiquitin","Ubiquitin-Activating Enzymes","Ubiquitin-Conjugating Enzymes","Ubiquitin-Protein Ligases","Ubiquitins"],"mesh_terms":["NEDD8 Protein","Cells, Cultured","Cyclopentanes","Gene Expression Regulation","Humans","Pyrimidines","Ubiquitins","Tumor Suppressor Protein p53","Ubiquitin","Ubiquitin-Conjugating Enzymes","Ubiquitin-Activating Enzymes","Ubiquitin-Protein Ligases","Hypoxia-Inducible Factor 1, alpha Subunit","Caspase 7"],"keywords":["NEDD8","Neddylation","Ubiquitin","Cell biology","Ubiquitin-conjugating enzyme","Chemistry","Enzyme","Ubiquitin ligase","Biochemistry","Biology","Gene","p53","Caspase 7","570","NEDD8 Protein","Ubiquitin-Protein Ligases","Cyclopentanes","Ubiquitin-Activating Enzymes","Hypoxia-Inducible Factor 1, alpha Subunit","Pyrimidines","Gene Expression Regulation","Ubiquitin-Conjugating Enzymes","Humans","Tumor Suppressor Protein p53","ubiquitin E1 enzyme","Molecular Biology","Ubiquitins","Cells, Cultured"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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