{"doi":"10.1016/j.jlr.2023.100420","title":"Reducing saturated fat intake lowers LDL-C but increases Lp(a) levels in African Americans: the GET-READI feeding trial","abstract":"Reducing dietary saturated fatty acids (SFA) intake results in a clinically significant lowering of LDL-C across ethnicities. In contrast, dietary SFA’s role in modulating emerging cardiovascular risk factors in different ethnicities remains poorly understood. Elevated levels of lipoprotein(a) [Lp(a)], an independent cardiovascular risk factor, disproportionally affect individuals of African descent. Here, we assessed the responses in Lp(a) levels to dietary SFA reduction in 166 African Americans enrolled in GET-READI (The Gene-Environment Trial on Response in African Americans to Dietary Intervention), a randomized controlled feeding trial. Participants were fed two diets in random order for five weeks each: (1) an average American diet (AAD) (37% total fat: 16% SFA), and (2) a diet similar to the Dietary Approaches to Stop Hypertension (DASH) diet (25% total fat: 6% SFA). The participants’ mean age was 35 years, 70% were women, the mean BMI was 28 kg/m2 and the mean LDL-C was 116 mg/dL. Compared to the AAD diet, LDL-C was reduced by the DASH-type diet (mean change: -12 mg/dL), as were total cholesterol (-16 mg/dL), HDL-C (-5 mg/dL), apoA-1 (-9 mg/dL) and apoB-100 (-5 mg/dL) (all p<0.0001). In contrast, Lp(a) levels increased following the DASH-type diet compared with AAD (median: 58 vs 44 mg/dL, p<0.0001). In conclusion, in a large cohort of African Americans, reductions in SFA intake significantly increased Lp(a) levels while reducing LDL-C. Future studies are warranted to elucidate mechanism(s) underlying the SFA reduction-induced increase in Lp(a) levels and its role in cardiovascular risk across populations.","journal":"Journal of Lipid Research","year":2023,"id":339987,"datarank":0.6396332513629607,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.21465124975452823,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.21465124975452823,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":11,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT00079703"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1073985,"name":"Muhammad Arif Khan","orcid":"0009-0000-4588-8670","position":1,"is_corresponding":false},{"id":1357,"name":"Wei Zhang","orcid":"0000-0002-0942-1245","position":2,"is_corresponding":false},{"id":367245,"name":"Heejung Bang","orcid":"0000-0002-5755-9951","position":3,"is_corresponding":false},{"id":267717,"name":"Jennifer Rood","orcid":"0000-0001-5848-2987","position":4,"is_corresponding":false},{"id":1074323,"name":"Marlene M. Most","orcid":null,"position":5,"is_corresponding":false},{"id":1073986,"name":"Michael Lefevre","orcid":"0000-0002-2046-3593","position":6,"is_corresponding":false},{"id":442449,"name":"Lars Berglund","orcid":"0000-0001-6705-1791","position":7,"is_corresponding":false},{"id":442444,"name":"Byambaa Enkhmaa","orcid":"0000-0002-1429-6864","position":8,"is_corresponding":false},{"id":1073984,"name":"Hayley G. Law","orcid":"0009-0006-9830-1048","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:10:49.535464Z","pmid":"37482217","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}