{"doi":"10.1016/j.jlr.2022.100288","title":"Lactation alters the relationship between liver lipid synthesis and hepatic fat stores in the postpartum period","abstract":"/min. Compared with formula-feeding women, we found that lactating women exhibited lower plasma VLDL-TG concentrations, similar IHTG content and similar contribution of DNL to total VLDL-TG production. These findings suggest that lactation lowers plasma VLDL-TG concentrations for reasons that are unrelated to IHTG and DNL. Surprisingly, we determined that the rate of appearance of nonesterified fatty acids was not related to IHTG in either group, and the expected positive association between DNL and IHTG was only significant in formula-feeding women. Further, in lactating women only, the higher the prolactin concentration, the lower the IHTG, while greater DNL strongly associated with elevations in VLDL-TG. In conclusion, we suggest that future studies should investigate the role of lactation and prolactin in liver lipid secretion and metabolism.","journal":"Journal of Lipid Research","year":2022,"id":266731,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":372221,"name":"Majid Mufaqam Syed‐Abdul","orcid":"0000-0002-2803-0274","position":1,"is_corresponding":false},{"id":372222,"name":"Brian M. Casey","orcid":"0000-0001-5452-3761","position":2,"is_corresponding":false},{"id":349800,"name":"Jeffry R. Alger","orcid":"0000-0003-1699-089X","position":3,"is_corresponding":false},{"id":14807,"name":"Yulun Liu","orcid":"0000-0002-2018-2935","position":4,"is_corresponding":false},{"id":372223,"name":"Elizabeth J. Parks","orcid":"0000-0001-5681-1097","position":5,"is_corresponding":false},{"id":372220,"name":"María A. Ramos-Román","orcid":"0000-0001-7090-162X","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T00:26:58.102271Z","pmid":"36162520","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}