{"doi":"10.1016/j.jiph.2023.01.019","title":"Clinical significance of immune checkpoint proteins in HPV-infected cervical cancer","abstract":null,"journal":"Journal of Infection and Public Health","year":2023,"id":617810,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1488709,"name":"Rui Huang","orcid":"0009-0001-0126-3086","position":1,"is_corresponding":false},{"id":1593398,"name":"Peihang Li","orcid":null,"position":2,"is_corresponding":false},{"id":392345,"name":"Xiang Liu","orcid":"0000-0002-9367-6549","position":3,"is_corresponding":false},{"id":1593402,"name":"Qingyu Huang","orcid":null,"position":4,"is_corresponding":false},{"id":1593404,"name":"Jinbo Yue","orcid":null,"position":5,"is_corresponding":false},{"id":497299,"name":"Chao Liu","orcid":"0000-0002-3807-9901","position":6,"is_corresponding":false},{"id":1052035,"name":"Wenxue Zou","orcid":"0000-0002-4151-4230","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical significance of immune checkpoint proteins in HPV-infected cervical cancer","abstract":"OBJECTIVE: To investigate T cell immunoreceptor with Ig and ITIM domain (TIGIT), V-domain Ig suppressor of T cell activation (VISTA), and lymphocyte-activation gene-3 (LAG-3) expression in pathological tissue of human papillomavirus (HPV)-infected cervical cancer (CC) patients and their relationship with patient prognosis. METHODS: Clinical data of 175 patients with HPV-infected CC were collected retrospectively. Tumor tissue sections were stained immunohistochemically for TIGIT, VISTA, and LAG-3. The Kaplan-Meier method calculated patient survival. Univariate and multivariate Cox proportional hazards models analyzed all potential risk factors for survival. RESULTS: When combined positive score (CPS)= 1 was used as the cut-off value, the Kaplan-Meier survival curve showed that the progression-free survival (PFS) and overall survival (OS) of patients with positive expression of TIGIT and VISTA are shorter (both p < 0.05). Univariate COX regression analysis showed that the positive expression of TIGIT and VISTA are related to patient PFS and OS (both HR>1.0 and p < 0.05). Multivariate COX regression analysis showed that TIGIT-positive patients had shorter OS and VISTA-positive patients had shorter PFS (both HR>1.0 and p < 0.05). There is no significant correlation between LAG-3 expression and PFS or OS. When CPS= 10 was used as the cut-off value, Kaplan-Meier survival curve showed that TIGIT-positive patients had shorter OS (p = 0.019). Univariate COX regression analysis showed that TIGIT-positive expression was associated with the OS of patients (HR=2.209, CI: 1.118-4.365, p = 0.023). However, multivariate COX regression analysis showed that TIGIT expression was not associated significantly with OS. There was no significant correlation between VISTA and LAG-3 expression and PFS or OS. CONCLUSION: TIGIT and VISTA are associated closely with HPV-infected CC prognosis and are effective biomarkers.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36801634","pmcid":null,"openalex_id":"https://openalex.org/W4318561896","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81871895","title":null},{"funder_name":"Shandong Province Natural Science Foundation","grant_id":"ZR2021QH006","title":null}],"total_grants":2,"fwci":3.3819,"citation_percentile":0.94068255,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":20},{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.jiph.2023.01.019","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jiph.2023.01.019","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1876034123000291?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1876034123000291?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36801634","host_type":"repository"},{"url":"https://doaj.org/article/4347cbb1eb064244a0413ae468acd84c","host_type":"repository"}],"fields_of_study":["Cancer Immunotherapy and Biomarkers","Immunotherapy and Immune Responses","Colorectal and Anal Carcinomas","Female","Humans","Immune Checkpoint Proteins","Uterine Cervical Neoplasms","Human Papillomavirus Viruses","Retrospective Studies","Papillomavirus Infections","Clinical Relevance","Prognosis","Receptors, Immunologic"],"mesh_terms":["Immune Checkpoint Proteins","Clinical Relevance","Human Papillomavirus Viruses","Uterine Cervical Neoplasms","Female","Humans","Prognosis","Receptors, Immunologic","Retrospective Studies","Papillomavirus Infections"],"keywords":["TIGIT","Proportional hazards model","Univariate analysis","Medicine","Oncology","Internal medicine","Survival analysis","Cervical cancer","Univariate","Cancer","Multivariate analysis","Immunotherapy","Multivariate statistics","HPV","Vista","Lag-3","Immune Checkpoints"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:41:08.939906Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}