{"doi":"10.1016/j.jiph.2018.04.005","title":"Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis","abstract":null,"journal":"Journal of Infection and Public Health","year":2018,"id":614638,"datarank":0.8137425026222106,"base_score":5.424950017481403,"endowment":5.424950017481403,"self_citation_contribution":0.8137425026222106,"citation_network_contribution":0.0,"self_endowment_contribution":0.8137425026222106,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":226,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1583890,"name":"Nor A. Emran","orcid":null,"position":1,"is_corresponding":false},{"id":1277824,"name":"Zaw Lin","orcid":null,"position":2,"is_corresponding":false},{"id":1583889,"name":"Myo T. Zaw","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis","abstract":"BACKGROUND: Rifampicin (RIF) plays a pivotal role in the treatment of tuberculosis due to its bactericidal effects. Because the action of RIF is on rpoB gene encoding RNA polymerase β subunit, 95% of RIF resistant mutations are present in rpoB gene. The majority of the mutations in rpoB gene are found within an 81bp RIF-resistance determining region (RRDR). METHODOLOGY: Literatures on RIF resistant mutations published between 2010 and 2016 were thoroughly reviewed. RESULTS: The most commonly mutated codons in RRDR of rpoB gene are 531, 526 and 516. The possibilities of absence of mutation in RRDR of rpoB gene in MDR-TB isolates in few studies was due to existence of other rare rpoB mutations outside RRDR or different mechanism of rifampicin resistance. CONCLUSION: Molecular methods which can identify extensive mutations associated with multiple anti-tuberculous drugs are in urgent need so that the research on drug resistant mutations should be extended.","is_dataset_classified":null,"base_score":5.424950017481403,"endowment":5.424950017481403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29706316","pmcid":null,"openalex_id":"https://openalex.org/W2800888530","authors":[],"funders":[],"total_grants":0,"fwci":11.0448,"citation_percentile":0.99143058,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":9},{"year":2020,"count":30},{"year":2021,"count":27},{"year":2022,"count":34},{"year":2023,"count":40},{"year":2024,"count":26},{"year":2025,"count":42},{"year":2026,"count":17}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.jiph.2018.04.005","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jiph.2018.04.005","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1876034118300418?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1876034118300418?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29706316","host_type":"repository"},{"url":"https://doaj.org/article/8d17cab3bb4c4772b00d4a14c9a2ab78","host_type":"repository"}],"fields_of_study":["Tuberculosis Research and Epidemiology","Diverse Scientific Research Studies","Mycobacterium research and diagnosis","Antibiotics, Antitubercular","DNA-Directed RNA Polymerases","Drug Resistance, Bacterial","Humans","Mutation, Missense","Mycobacterium tuberculosis","Rifampin","Tuberculosis"],"mesh_terms":["Antibiotics, Antitubercular","Humans","Mycobacterium tuberculosis","Rifampin","DNA-Directed RNA Polymerases","Tuberculosis","Mutation, Missense","Drug Resistance, Bacterial"],"keywords":["rpoB","Rifampicin","Mycobacterium tuberculosis","Tuberculosis","Microbiology","Medicine","Gene","Biology","Virology","Genetics","Pathology","Mutations","rpoB gene","Rifampicin Resistance","Rifampicin-resistance Determining Region"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T14:53:16.460098Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}