{"doi":"10.1016/j.jinf.2012.09.013","title":"The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression","abstract":null,"journal":"Journal of Infection","year":2013,"id":635067,"datarank":0.7622106547476696,"base_score":5.081404364984463,"endowment":5.081404364984463,"self_citation_contribution":0.7622106547476696,"citation_network_contribution":0.0,"self_endowment_contribution":0.7622106547476696,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":160,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1391806,"name":"Carolina Gutiérrez","orcid":"0000-0001-7407-9258","position":1,"is_corresponding":false},{"id":528294,"name":"Alejandro Vallejo","orcid":"0000-0001-5360-878X","position":2,"is_corresponding":false},{"id":1647427,"name":"Beatriz Hernández-Novoa","orcid":null,"position":3,"is_corresponding":false},{"id":684978,"name":"Laura Díaz","orcid":"0000-0002-5033-0900","position":4,"is_corresponding":false},{"id":1647430,"name":"María Abad Fernández","orcid":null,"position":5,"is_corresponding":false},{"id":1647431,"name":"Nadia Madrid","orcid":null,"position":6,"is_corresponding":false},{"id":1647432,"name":"Fernando Dronda","orcid":null,"position":7,"is_corresponding":false},{"id":96083,"name":"Javier Zamora","orcid":"0000-0003-4901-588X","position":8,"is_corresponding":false},{"id":1647433,"name":"María Ángeles Muñoz-Fernández","orcid":null,"position":9,"is_corresponding":false},{"id":428869,"name":"Santiago Moreno","orcid":"0000-0002-2843-1094","position":10,"is_corresponding":false},{"id":1647424,"name":"Sergio Serrano-Villar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression","abstract":"<h4>Objectives</h4>HIV-infected subjects on antiretroviral therapy often fail to normalize the CD4/CD8 ratio despite CD4 count normalization. We aimed to analyze the biological significance of this finding.<h4>Methods</h4>Cross-sectional analysis in 20 HIV-infected subjects on stable triple-ART, plasma HIV RNA <40 copies/mL for at least 2 years and CD4 count >350 cells/mm(3). Laboratory measurements included T-cell activation (HLADR(+), CD38(+)) and senescence (CD57(+)), lipopolysaccharide (LPS), sCD14 and the HIV latent reservoir (number of latently infected memory CD4 cells carrying replication-competent virus).<h4>Results</h4>CD4/CD8 ratio was positively correlated with CD4 nadir (r = 0.468, p = 0.038) and accumulated ART exposure (r = 0.554, p = 0.0011), and negatively with viral load before ART initiation (r = -0.547, p = 0.013), CD4(+)HLADR(+)CD38(+) T-cells (r = -0.428, p = 0.086) and CD8(+)CD57(+) T-cells (r = -0.431, p = 0.084). No associations with LPS, sCD14 or HIV latent reservoir were found. After the multivariate analyses, the CD4/CD8 ratio remained independently associated with CD4(+)HLADR(+)CD38(+) T-cells and CD8(+)HLADR(+) T-cells.<h4>Conclusions</h4>In our study in subjects on suppressive ART the CD4/CD8 ratio was independently associated with T-cell activation. Our results must be confirmed in larger studies, as this parameter might be a useful clinical tool to identify subjects with ongoing immune activation despite long-term viral suppression.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23046968","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0163445312002812?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0163445312002812?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["T-Lymphocytes","Humans","HIV Infections","Cyclohexanes","Triazoles","Pyrrolidinones","Anti-Retroviral Agents","CD4-CD8 Ratio","Viral Load","Multivariate Analysis","Risk Factors","Statistics, Nonparametric","Cross-Sectional Studies","Lymphocyte Activation","Bacterial Translocation","Adult","Middle Aged","Female","Male","Clinical Trials, Phase II as Topic","Host-Pathogen Interactions","Raltegravir Potassium","Maraviroc"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:35:57.004274Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}