{"doi":"10.1016/j.jid.2025.08.020","title":"microRNA-223 Expression during Flares in Patients with Generalized Pustular Psoriasis Is Regulated by Spesolimab Treatment","abstract":"Generalized pustular psoriasis (GPP) is a systemic, neutrophilic inflammatory disease characterized by chronic symptoms and periods of flaring. GPP is associated with significant morbidity, and GPP flares are potentially life threatening if left untreated (Puig et al, 2023). GPP pathogenesis involves dysregulated IL-36 signaling, thus highlighting IL-36 pathway blockade as a promising therapeutic target (Hawkes et al, 2023). Spesolimab, an IL-36 receptor antagonist, has shown efficacy in various trials (Bachelez et al, 2021, 2019; Morita et al, 2023).","journal":"Journal of Investigative Dermatology","year":2025,"id":526702,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":335760,"name":"Marcel Rolser","orcid":null,"position":1,"is_corresponding":false},{"id":19161,"name":"Christian T. Wohnhaas","orcid":"0000-0002-1450-9284","position":2,"is_corresponding":false},{"id":1402820,"name":"Janine Roy","orcid":"0000-0002-8330-9702","position":3,"is_corresponding":false},{"id":1402821,"name":"Kolja Becker","orcid":"0000-0001-8282-5329","position":4,"is_corresponding":false},{"id":1402822,"name":"Anjli Kukreja","orcid":"0009-0008-0348-2021","position":5,"is_corresponding":false},{"id":1402823,"name":"Christian Thoma","orcid":"0000-0002-5702-2492","position":6,"is_corresponding":false},{"id":18939,"name":"James G. Krueger","orcid":"0000-0002-3775-1778","position":7,"is_corresponding":false},{"id":1402819,"name":"Denis Delić","orcid":"0000-0003-0233-8374","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:50:34.851930Z","pmid":"40885519","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}