{"doi":"10.1016/j.jid.2024.12.010","title":"Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation","abstract":"The skin is a major contributor to the age-associated rise in systemic inflammation, known as “inflammaging” (Yang et al, 2023; Ye et al, 2019). Previous research from our laboratory has shown that restoring epidermal barrier function in older mice, through application of a topical emollient, can normalize serum cytokine levels to those seen in young age (Hu et al, 2017; Man et al, 2015). This not only demonstrates that the skin is a major source of age-related systemic inflammation but also serves as proof of concept that this inflammation is amenable to treatment.","journal":"Journal of Investigative Dermatology","year":2024,"id":452127,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":527282,"name":"Anna Celli","orcid":"0000-0002-0605-0362","position":1,"is_corresponding":false},{"id":353032,"name":"Jiechen Zhang","orcid":"0000-0002-5256-8672","position":2,"is_corresponding":false},{"id":281774,"name":"Jeanmarie R. Gonzalez","orcid":"0000-0001-8998-7726","position":3,"is_corresponding":false},{"id":554111,"name":"Jason M. Meyer","orcid":"0000-0003-1327-3510","position":4,"is_corresponding":false},{"id":1274421,"name":"Brook Abegaze","orcid":null,"position":5,"is_corresponding":false},{"id":501173,"name":"Merisa Piper","orcid":"0000-0002-9458-3782","position":6,"is_corresponding":false},{"id":254311,"name":"Peter M. Elias","orcid":"0000-0001-7989-4032","position":7,"is_corresponding":false},{"id":588822,"name":"Katrina Abuabara","orcid":"0000-0002-7736-6946","position":8,"is_corresponding":false},{"id":593626,"name":"Carl Grünfeld","orcid":"0000-0003-3501-4421","position":9,"is_corresponding":false},{"id":254310,"name":"Mao‐Qiang Man","orcid":"0000-0002-0957-4903","position":10,"is_corresponding":false},{"id":501175,"name":"Tiffany C. Scharschmidt","orcid":"0000-0001-5517-089X","position":11,"is_corresponding":false},{"id":94236,"name":"Theodora M. Mauro","orcid":"0000-0003-3623-0070","position":12,"is_corresponding":false},{"id":1274420,"name":"T Richard Parenteau","orcid":null,"position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T02:02:50.407779Z","pmid":"39746572","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}