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DSG-specific T cells play a central role in PV pathogenesis because they provide help to autoreactive B cells for autoantibody production. In this study, we characterized DSG3-specific peripheral T cells in a cohort of 52 patients with PV and 41 healthy controls with regard to cytokine profile and epitope specificity. By ELISpot analysis, type 2 T cells reactive with the DSG3 ectodomain were significantly increased in patients with PV compared with those in healthy controls. By dextramer analysis, CD4+ T cells specific for an epitope within the extracellular domain of DSG3, DSG3<sub>(206-220)</sub>, were found at significantly higher frequencies in patients with PV than in HLA-matched healthy controls. T-cell recognition of two distinct DSG3 epitopes, that is, DSG3<sub>(206-220)</sub> and DSG3<sub>(378-392)</sub>, correlated significantly, suggesting a synergistic effect in B-cell help. Immunization of HLA-DRB1∗04:02-transgenic mice with PV with the same set of DSG3 peptides induced pathogenic DSG3-specific IgG antibodies, which induced loss of keratinocyte adhesion in vitro. Thus, DSG3 peptide-specific T cells are of particular interest as surrogate markers of disease activity and potential therapeutic targets in PV.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37717934","pmcid":null,"openalex_id":"https://openalex.org/W4386760019","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"1602/17-1","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"EM 80/3-2","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"GA545/6-2","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"He1602/7-3","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SI-1281/6-1","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"Ti 291/10-2","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":7,"fwci":2.4673,"citation_percentile":0.89380272,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":9},{"year":2026,"count":3}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.jidonline.org/article/S0022202X23025769/pdf","host_type":"journal"},{"url":"http://www.jidonline.org/article/S0022202X23025769/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022202X23025769?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022202X23025769?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jid.2023.07.025","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37717934","host_type":"repository"},{"url":"https://boris.unibe.ch/186375/","host_type":"repository"},{"url":"https://dx.doi.org/10.48350/186375","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.jid.2023.07.025","host_type":""}],"fields_of_study":["Autoimmune Bullous Skin Diseases","Urticaria and Related Conditions","Coagulation, Bradykinin, Polyphosphates, and Angioedema","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Animals","Epitopes","Autoantibodies","Humans","Immunoglobulin G","Mice, Transgenic","Pemphigus","Peptides","Desmoglein 1","Desmoglein 3","Mice"],"keywords":["Desmoglein 3","Pemphigus vulgaris","Desmoglein","Immunology","Ectodomain","Epitope","Pemphigus","ELISPOT","Autoantibody","Desmoglein 1","T cell","Medicine","Antibody","Immune system","Internal medicine","610","Mice, Transgenic","Mice","Epitopes","Immunoglobulin G","Animals","Humans","Peptides","Autoantibodies"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:21:51.902426Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}