{"doi":"10.1016/j.jid.2022.12.021","title":"Characterizing Dermal Transcriptional Change in the Progression from Sun-Protected Skin to Actinic Keratosis","abstract":"Understanding early tumorigenic events have obvious diagnostic and prognostic implications, particularly in the skin since this is the site of more US cancer diagnoses than any other organ (Rogers et al., 2015Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the U.S. Population, 2012. JAMA Dermatol 2015;151(10):1081-1086.Google Scholar). Actinic keratosis (AK) are dysplastic keratinocyte lesions characterized by irregularly shaped scaly papules frequently manifesting on sun-damaged skin, and are considered precursor lesions which can develop into cutaneous squamous cell carcinoma (cSCC), the second most common keratinocyte cancer (Siegel et al., 2017Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin 2017;67(1):7-30.Google Scholar). Delineating the molecular events that characterize transition from normal skin to AK and on to established skin cancer has been the focus of a growing number of studies employing various technologies to identify markers of both initiation and progression of AK and cSCC (Chitsazzadeh et al., 2016Chitsazzadeh V. Coarfa C. Drummond J.A. Nguyen T. Joseph A. Chilukuri S. et al.Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.Nat Commun. 2016; 712601Crossref PubMed Scopus (91) Google Scholar, Hameetman et al., 2013Hameetman L. Commandeur S. Bavinck J.N. Wisgerhof H.C. de Gruijl F.R. Willemze R. et al.Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.BMC Cancer. 2013; 13: 58Crossref PubMed Scopus (67) Google Scholar, Kim et al., 2021Kim Y.S. Shin S. Jung S.H. Park Y.M. Park G.S. Lee S.H. et al.Genomic Progression of Precancerous Actinic Keratosis to Squamous Cell Carcinoma.J Invest Dermatol. 2021; Google Scholar, Lambert et al., 2014Lambert S.R. Mladkova N. Gulati A. Hamoudi R. Purdie K. Cerio R. et al.Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling.Br J Cancer. 2014; 110: 520-529Crossref PubMed Scopus (68) Google Scholar, Padilla et al., 2010Padilla R.S. Sebastian S. Jiang Z. Nindl I. Larson R. Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: a spectrum of disease progression.Arch Dermatol. 2010; 146: 288-293Crossref PubMed Scopus (101) Google Scholar, Ra et al., 2011Ra S.H. Li X. Binder S. Molecular discrimination of cutaneous squamous cell carcinoma from actinic keratosis and normal skin.Mod Pathol. 2011; 24: 963-973Abstract Full Text Full Text PDF PubMed Scopus (40) Google Scholar, Thomson et al., 2021Thomson J. Bewicke-Copley F. Anene C.A. Gulati A. Nagano A. Purdie K. et al.The Genomic Landscape of Actinic Keratosis.J Invest Dermatol. 2021; 141: 1664-16674 e7Abstract Full Text Full Text PDF Scopus (12) Google Scholar, Zheng et al., 2021Zheng Q. Capell B.C. Parekh V. O'Day C. Atillasoy C. Bashir H.M. et al.Whole-Exome and Transcriptome Analysis of UV-Exposed Epidermis and Carcinoma In Situ Reveals Early Drivers of Carcinogenesis.J Invest Dermatol. 2021; 141: 295-307 e13Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar). Traditionally, cancer biology focusses on change within the tumor compartment for diagnosis and staging. Recent genomic profiling of AK has been similar as multiple studies have focused on DNA analysis to identify clonal chromosomal abnormalities and somatic mutations (Kim et al., 2021Kim Y.S. Shin S. Jung S.H. Park Y.M. Park G.S. Lee S.H. et al.Genomic Progression of Precancerous Actinic Keratosis to Squamous Cell Carcinoma.J Invest Dermatol. 2021; Google Scholar, Thomson et al., 2021Thomson J. Bewicke-Copley F. Anene C.A. Gulati A. Nagano A. Purdie K. et al.The Genomic Landscape of Actinic Keratosis.J Invest Dermatol. 2021; 141: 1664-16674 e7Abstract Full Text Full Text PDF Scopus (12) Google Scholar), and transcriptional an","journal":"Journal of Investigative Dermatology","year":2023,"id":376446,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":452909,"name":"Clara Curiel‐Lewandrowski","orcid":"0000-0001-8982-6252","position":1,"is_corresponding":false},{"id":1139264,"name":"Edgar Tapia","orcid":"0000-0002-8211-1008","position":2,"is_corresponding":false},{"id":1139265,"name":"Joel Parker","orcid":"0000-0002-3411-3818","position":3,"is_corresponding":false},{"id":721808,"name":"Lisa White","orcid":"0000-0002-1735-912X","position":4,"is_corresponding":false},{"id":713921,"name":"H.‐H. 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