{"doi":"10.1016/j.jhep.2008.03.014","title":"Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury","abstract":null,"journal":"Journal of Hepatology","year":2008,"id":657698,"datarank":1.8573430169782894,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":1.3522486424803182,"self_endowment_contribution":0.5050943744979712,"citer_contribution":1.3522486424803182,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":26,"citers_with_citation_signal":24,"citers_with_endowment":24,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1716881,"name":"Vicki Hoagland","orcid":null,"position":1,"is_corresponding":false},{"id":1716882,"name":"Whitney Benz","orcid":null,"position":2,"is_corresponding":false},{"id":1041775,"name":"Kimberly J. Riehle","orcid":"0000-0003-4742-0910","position":3,"is_corresponding":false},{"id":296017,"name":"Jean S. Campbell","orcid":"0000-0002-9187-2204","position":4,"is_corresponding":false},{"id":1716884,"name":"Denny H. Liggitt","orcid":null,"position":5,"is_corresponding":false},{"id":800320,"name":"Nelson Fausto","orcid":null,"position":6,"is_corresponding":false},{"id":1716880,"name":"Lorrie A. Langdale","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury","abstract":"<h4>Background/aims</h4>Preservation of function requires tight regulation of the cellular events initiated when hepatic ischemia is followed by reperfusion (IR). One important mechanism modulating the cytokine-directed response to injury is Suppressors of Cytokine Signaling. SOCS1 and SOCS3 ensure appropriate intensity and duration of cytokine signaling through negative feedback on JAK-STAT signaling. The contribution of SOCS1 and SOCS3-mediated regulation to the evolution of hepatic IR injury is unknown.<h4>Methods</h4>C57Blk6 mice were subjected to mild (20 min) or severe (90 min) hepatic ischemia. Liver was analyzed for cytokine and SOCS1/3 induction as well as JAK-STAT activation at intervals after reperfusion.<h4>Results</h4>Tnf, Il-1beta, and Il-6 expression paralleled increasing injury severity. Despite early phosphorylation of both STAT1 and STAT3 after severe injury, only nuclear translocation of activated STAT3, suggesting that the induction of target genes through JAK-STAT after IR is predominantly via STAT3. Socs3 was expressed across the injury spectrum while Socs1 was induced only in the face of severe IR injury. Severe IR in Il-6 deficient mice confirmed that Il-6, acting via STAT3, serves as a primary inducer of both regulatory mechanisms.<h4>Conclusions</h4>Under the influence of IL-6-mediated STAT3 signaling, Socs1 serves as a complimentary regulatory mechanism when Socs3 is insufficient to limit cytokine-mediated inflammation after hepatic IR.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18471922","pmcid":"PMC2536594","openalex_id":"https://openalex.org/W2070114201","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA-127228","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA-23226","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R37 CA023226","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA127228","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA023226","title":null}],"total_grants":5,"fwci":1.2905,"citation_percentile":0.80079072,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":5},{"year":2017,"count":1},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2536594","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2536594","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0168827808002262?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168827808002262?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jhep.2008.03.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18471922","host_type":"repository"}],"fields_of_study":["Cytokine Signaling Pathways and Interactions","Organ Transplantation Techniques and Outcomes","Liver Disease and Transplantation"],"mesh_terms":["Suppressor of Cytokine Signaling 1 Protein","Suppressor of Cytokine Signaling 3 Protein","Animals","Liver","Liver Diseases","Male","Mice, Inbred C57BL","Severity of Illness Index","Tumor Necrosis Factor-alpha","Signal Transduction","Reperfusion Injury","Interleukin-6","Mice, Knockout","Gene Expression Profiling","STAT1 Transcription Factor","STAT3 Transcription Factor","Suppressor of Cytokine Signaling Proteins","Mice","Interleukin-1beta"],"keywords":["Reperfusion injury","Cytokine","Ischemia","SOCS3","Medicine","Signal transduction","Immunology","Suppressor","Cell biology","Internal medicine","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:03:40.918453Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}