{"doi":"10.1016/j.jhep.2007.09.008","title":"The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection","abstract":null,"journal":"Journal of Hepatology","year":2008,"id":632251,"datarank":0.6496100010429497,"base_score":4.330733340286331,"endowment":4.330733340286331,"self_citation_contribution":0.6496100010429497,"citation_network_contribution":0.0,"self_endowment_contribution":0.6496100010429497,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":75,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1638789,"name":"Mirko Moreno Zaldivar","orcid":null,"position":1,"is_corresponding":false},{"id":1572752,"name":"Marie-Luise Berres","orcid":null,"position":2,"is_corresponding":false},{"id":1638790,"name":"Alexa Werth","orcid":null,"position":3,"is_corresponding":false},{"id":620527,"name":"David Scholten","orcid":"0000-0002-4604-1620","position":4,"is_corresponding":false},{"id":1638791,"name":"Sonja Hillebrandt","orcid":null,"position":5,"is_corresponding":false},{"id":569,"name":"Frank Tacke","orcid":"0000-0001-6206-0226","position":6,"is_corresponding":false},{"id":1638792,"name":"Petra Schmitz","orcid":null,"position":7,"is_corresponding":false},{"id":74474,"name":"Edgar Dahl","orcid":"0000-0002-8439-7994","position":8,"is_corresponding":false},{"id":1638793,"name":"Tonio Wiederholt","orcid":null,"position":9,"is_corresponding":false},{"id":1638794,"name":"Claus Hellerbrand","orcid":null,"position":10,"is_corresponding":false},{"id":262977,"name":"Thomas Berg","orcid":"0000-0003-0003-6241","position":11,"is_corresponding":false},{"id":440349,"name":"Ralf Weiskirchen","orcid":"0000-0003-3888-0931","position":12,"is_corresponding":false},{"id":110022,"name":"Christian Trautwein","orcid":"0000-0003-2762-8247","position":13,"is_corresponding":false},{"id":263006,"name":"Frank Lammert","orcid":"0000-0003-4450-7201","position":14,"is_corresponding":false},{"id":1638788,"name":"Hermann E. Wasmuth","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection","abstract":"<h4>Background/aims</h4>The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis.<h4>Methods</h4>A genotype analysis of CX3CR1 variants was performed in 211 HCV-infected patients. Hepatic expression of CX3CR1 was studied in HCV-infected livers and isolated liver cell populations by RT-PCR and immunohistochemistry. The effects of fractalkine on mRNA expression of profibrogenic genes were determined in isolated hepatic stellate cells (HSC) and CX3CR1 genotypes were related to intrahepatic TIMP-1 mRNA levels.<h4>Results</h4>The intrahepatic mRNA expression of CX3CR1 correlates with the stage of HCV-induced liver fibrosis (P=0.03). The CX3CR1 coding variant V249I is associated with advanced liver fibrosis, independent of the T280M variant (P=0.009). CX3CR1 is present on primary HSC and fractalkine leads to a suppression of tissue inhibitor of metalloproteinase (TIMP)-1 mRNA in HSC (P=0.03). Furthermore, CX3CR1 genotypes are associated with TIMP-1 mRNA expression in HCV-infected liver (P=0.03).<h4>Conclusions</h4>The results identify the fractalkine receptor CX3CR1 as susceptibility a gene for hepatic fibrosis in HCV infection. The modulation of TIMP-1 expression by fractalkine and CX3CR1 genotypes provides functional support for the observed genotype-phenotype association.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18078680","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0168827807005740?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168827807005740?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Liver","Humans","Hepatitis C, Chronic","Liver Cirrhosis","Receptors, Chemokine","Tissue Inhibitor of Metalloproteinase-1","RNA, Messenger","Genotype","Polymorphism, Single Nucleotide","CX3C Chemokine Receptor 1"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:19:09.534292Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}