{"doi":"10.1016/j.jhazmat.2019.120908","title":"Evaluation of single and combined toxicity of bisphenol A and its analogues using a highly-sensitive micro-biosensor","abstract":null,"journal":"Journal of Hazardous Materials","year":2020,"id":654767,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1708908,"name":"Guanlan Wu","orcid":null,"position":1,"is_corresponding":false},{"id":1366533,"name":"Yi Xing","orcid":"0000-0002-3180-7822","position":2,"is_corresponding":false},{"id":1708909,"name":"Chengzhi Wang","orcid":null,"position":3,"is_corresponding":false},{"id":1708910,"name":"Xing Yuan","orcid":null,"position":4,"is_corresponding":false},{"id":642517,"name":"Baikun Li","orcid":"0000-0002-5623-5912","position":5,"is_corresponding":false},{"id":208203,"name":"Xiaolin Zhu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Evaluation of single and combined toxicity of bisphenol A and its analogues using a highly-sensitive micro-biosensor","abstract":"Bisphenol analogues have been developed as alternatives to bisphenol A (BPA), a common chemical with potential adverse effects on human health. It is imperative to perform a fast and sensitive evaluation for the toxicity of these bisphenol analogues. This study introduces a label-free electrochemical biosensor based on a screen-printed electrode modified with the carboxylated multi-walled carbon nanotube/rhodamine B/gold nanoparticle. Ctenopharyngodon idella kidney (CIK) cells were used as the biological recognition agent to detect changes in electrochemical signals and indicate the cell viability. Only 20 μL of sample was required for detection, which was much lower than that of other conventional electrochemical methods (≥ 1 mL). This biosensor was examined for the cytotoxicity of BPA, bisphenol AF (BPAF), bisphenol B (BPB), bisphenol F (BPF), and bisphenol S (BPS) to CIK cells. The half inhibition concentration (IC<sub>50</sub>) values after 48 h of exposure indicated that the rank order of cytotoxicities was BPAF > BPB > BPA > BPF > BPS. The morphological changes in CIK cells after treatment with various bisphenols were investigated, and the combined toxicities of the binary bisphenol mixtures were determined. Potentially synergistic and additive effects were observed. These findings provide new insights into the cytotoxicity of bisphenol analogues.","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31352154","pmcid":null,"openalex_id":"https://openalex.org/W2956822710","authors":[],"funders":[{"funder_name":"China Postdoctoral Science Foundation","grant_id":"","title":null},{"funder_name":"Department of Science and Technology of Jilin Province","grant_id":"","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"","title":null}],"total_grants":4,"fwci":2.3291,"citation_percentile":0.8725836,"influential_citations":0,"citation_trend":[{"year":2020,"count":6},{"year":2021,"count":6},{"year":2022,"count":11},{"year":2023,"count":11},{"year":2024,"count":6},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304389419308611?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304389419308611?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jhazmat.2019.120908","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31352154","host_type":"repository"}],"fields_of_study":["Effects and risks of endocrine disrupting chemicals","Animal testing and alternatives","Advanced biosensing and bioanalysis techniques"],"mesh_terms":["Animals","Benzhydryl Compounds","Carps","Cell Line","Gold","Phenols","Rhodamines","Biosensing Techniques","Nanotubes, Carbon","Metal Nanoparticles"],"keywords":["Bisphenol A","Bisphenol","Bisphenol S","Biosensor","Chemistry","Cytotoxicity","Chromatography","Nuclear chemistry","Organic chemistry","Biochemistry","In vitro","CIK cells","Combined toxicity","Screen Printed Electrode","Bisphenol Analogues","Micro-biosensor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T08:17:22.190437Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}