{"doi":"10.1016/j.jgr.2025.10.002","title":"American ginseng (Panax quinquefolius L.) extracts (G1899) reverse stress-induced behavioral abnormalities in mice","abstract":"Background: L.) extracts (G1899) improve cognition. Methods: We examined whether G1899 showed protective effects on stress-induced behavioral changes in animals. 200 mg/kg G1899 was orally administered daily for 4 weeks to 2-3-month-old female and male mice before inducing stress. To induce acute stress in animals, we intraperitoneally injected a low dose of lipopolysaccharides (LPS) (10 μg/kg), and saline was used as a control. We also used chronic restraint stress (CRS) as a chronic stress model in mice. After LPS injection or CRS, multiple behavioral assays were carried out - a sucrose preference test, an open filed test, reciprocal social interaction, contextual fear conditioning, and a tail suspension test - to determine whether acute or chronic stress affected animals' behaviors and whether G1899 had protective effects against stress-induced behavioral dysfunction. Results: We found that both LPS injection and CRS induced stress-related behavioral dysfunction, including depression-like behavior, anhedonia, social dysfunction, and fear memory impairments in mice. However, G1899 was sufficient to reverse stress-induced behavioral abnormalities in animals. Our data further suggested that G1899 reduced the activity of hippocampal neurons by suppressing glutamatergic activity. Conclusion: G1899 supplements can be protective against both acute and chronic stress in mice by suppressing neuronal and synaptic activity.","journal":"Journal of Ginseng Research","year":2025,"id":536848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9429,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994658,"name":"McKennon J. Wiles","orcid":null,"position":1,"is_corresponding":false},{"id":1327961,"name":"Ellison R. Black","orcid":null,"position":2,"is_corresponding":false},{"id":1196909,"name":"Seung Hyun Roh","orcid":"0009-0006-1008-9047","position":3,"is_corresponding":false},{"id":994657,"name":"Evelina Bouckova","orcid":null,"position":4,"is_corresponding":false},{"id":994659,"name":"Madison H. Wustrau","orcid":null,"position":5,"is_corresponding":false},{"id":1422683,"name":"Joshua C. Flowers","orcid":null,"position":6,"is_corresponding":false},{"id":1422684,"name":"Paige E. Vetter","orcid":null,"position":7,"is_corresponding":false},{"id":268413,"name":"Jaehoon Lee","orcid":"0000-0002-4508-3845","position":8,"is_corresponding":false},{"id":1422685,"name":"Byung‐Cheol Han","orcid":null,"position":9,"is_corresponding":false},{"id":266911,"name":"Seonil Kim","orcid":"0000-0002-0451-2180","position":10,"is_corresponding":false},{"id":1070868,"name":"Rahmi Lee","orcid":"0000-0002-6955-1383","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:52:09.056872Z","pmid":"41550593","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}