{"doi":"10.1016/j.jgg.2026.02.002","title":"The ultra-conserved lncRNA Crnde regulates neural differentiation by targeting Gbx2 during embryonic development of the thalamus","abstract":"The thalamus regulates sensory processing, cognition, and sleep, yet the molecular mechanisms underlying its development remain incompletely understood. Long noncoding RNAs (lncRNAs), particularly evolutionarily conserved ones, are highly enriched in the brain. Using public mRNA databases, we screen for lncRNAs with embryonic brain expression and harboring ultraconserved non-coding elements (UCNEs) in humans and mice, identifying colorectal neoplasia differentially expressed (Crnde). It exhibits stage-specific upregulation in the embryonic thalamus. The Database of Genomic Variation and Phenotype in Humans using Ensembl Resources (DECIPHER) database suggests a potential association between Crnde and intellectual disability. Crnde-deficient mice display anxiety-like behaviors and spatial memory deficits. Furthermore, Crnde ablation increases progenitor cell numbers and impairs neuronal differentiation during embryonic thalamic development. Mechanistically, Crnde modulates the mRNA expression of gastrulation brain homeobox 2 (Gbx2), a gene critical for thalamic development. Collectively, our results implicate lncRNA Crnde in the proper progression of embryonic thalamic development in mice.","journal":"Journal of Genetics and Genomics","year":2026,"id":7206,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0648,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2026-02-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":64949,"name":"Ya-Yun Gu","orcid":null,"position":1,"is_corresponding":false},{"id":64950,"name":"Yuan-Lin He","orcid":null,"position":2,"is_corresponding":false},{"id":64951,"name":"Yuan Hong","orcid":null,"position":3,"is_corresponding":false},{"id":64952,"name":"Yue-Wen He","orcid":null,"position":4,"is_corresponding":false},{"id":64953,"name":"Zi-Cheng Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":64954,"name":"Yuan-Hao Wang","orcid":null,"position":6,"is_corresponding":false},{"id":64955,"name":"Jia-Ning Sun","orcid":null,"position":7,"is_corresponding":false},{"id":52493,"name":"Xiao Han","orcid":"0000-0002-9305-5590","position":8,"is_corresponding":false},{"id":31471,"name":"Melina Claussnitzer","orcid":"0000-0003-2450-736X","position":9,"is_corresponding":false},{"id":64956,"name":"Zhi-Bin Hu","orcid":"0000-0002-8277-5234","position":10,"is_corresponding":false},{"id":64957,"name":"Yayun Gu","orcid":"0000-0002-6893-311X","position":11,"is_corresponding":false},{"id":64958,"name":"Hong Yuan","orcid":null,"position":12,"is_corresponding":false},{"id":64959,"name":"Yuewen He","orcid":"0000-0002-4078-5100","position":13,"is_corresponding":false},{"id":21173,"name":"Y. Wang","orcid":"0000-0003-4693-5365","position":14,"is_corresponding":false},{"id":64948,"name":"Wen-Zhu Hu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}