{"doi":"10.1016/j.jgg.2021.03.015","title":"The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research","abstract":null,"journal":"Journal of Genetics and Genomics","year":2021,"id":588272,"datarank":0.8039442955720015,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.3211129218417713,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.3211129218417713,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":20,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1504940,"name":"Emmanuel M. 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In addition, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research, such as animal breeding, vaccine development, xenotransplantation, and disease modeling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34144928","pmcid":null,"openalex_id":"https://openalex.org/W3162049976","authors":[],"funders":[{"funder_name":"National Transgenic Science and Technology Program","grant_id":"2016ZX08006003-004","title":null},{"funder_name":"National Transgenic Science and Technology Program","grant_id":"2018ZX08009-26B","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31941008","title":null},{"funder_name":"Natural Science Foundation of Anhui Province","grant_id":"2008085QC138","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"2662018JC002","title":null},{"funder_name":"Consortium of International Agricultural Research Centers","grant_id":"","title":null}],"total_grants":6,"fwci":1.1104,"citation_percentile":0.76356917,"influential_citations":0,"citation_trend":[{"year":2022,"count":4},{"year":2023,"count":7},{"year":2024,"count":4},{"year":2025,"count":8},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1673852721000990?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1673852721000990?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jgg.2021.03.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34144928","host_type":"repository"},{"url":"https://hdl.handle.net/10568/113738","host_type":"repository"}],"fields_of_study":["CRISPR and Genetic Engineering","Virus-based gene therapy research","Viral Infectious Diseases and Gene Expression in Insects","Animals","Animals, Genetically Modified","Breeding","CRISPR-Cas Systems","Disease Resistance","Gene Editing","Genetic Association Studies","Genetic Engineering","Humans","Models, Animal","Quantitative Trait Loci","Quantitative Trait, Heritable","Research","Swine"],"mesh_terms":["Gene Editing","Animals","Breeding","Genetic Engineering","Humans","Research","Swine","Quantitative Trait, Heritable","Models, Animal","Animals, Genetically Modified","Quantitative Trait Loci","Genetic Association Studies","Disease Resistance","CRISPR-Cas Systems"],"keywords":["CRISPR","Genome editing","Biology","Cas9","Xenotransplantation","Computational biology","Genetics","Biotechnology","Gene","Transplantation","Medicine","Swine","Crispr/cas9","Base Editing","Crispr Screening"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.23972928.v1","title":"Additional file 1 of Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.23972928","title":"Additional file 1 of Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-20T02:31:44.323558Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}