{"doi":"10.1016/j.jgar.2025.07.005","title":"Emerging epidemic of the predominant clusters of FC428-like Neisseria gonorrhoeae in Guangdong, China","abstract":null,"journal":"Journal of Global Antimicrobial Resistance","year":2025,"id":656818,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1714490,"name":"Xiao-lin Qin","orcid":null,"position":1,"is_corresponding":false},{"id":1213809,"name":"Han Zhou","orcid":"0000-0001-9608-6897","position":2,"is_corresponding":false},{"id":1714491,"name":"Xing-zhong Wu","orcid":null,"position":3,"is_corresponding":false},{"id":1714492,"name":"Wen-tao Chen","orcid":null,"position":4,"is_corresponding":false},{"id":1714494,"name":"Zi-yan Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":1714495,"name":"Qing-xian Zhan","orcid":null,"position":6,"is_corresponding":false},{"id":1714497,"name":"Zhan-qin Feng","orcid":null,"position":7,"is_corresponding":false},{"id":1714499,"name":"Yao-hua Xue","orcid":null,"position":8,"is_corresponding":false},{"id":1714502,"name":"Yong-fei Hu","orcid":null,"position":9,"is_corresponding":false},{"id":1714505,"name":"Chi-xing Guo","orcid":null,"position":10,"is_corresponding":false},{"id":268593,"name":"Feng Wang","orcid":"0000-0002-1233-2745","position":11,"is_corresponding":false},{"id":897578,"name":"Ming Li","orcid":"0000-0001-6665-8559","position":12,"is_corresponding":false},{"id":1714508,"name":"Zhi-zhou Wu","orcid":null,"position":13,"is_corresponding":false},{"id":1714509,"name":"Jian-hong Xie","orcid":null,"position":14,"is_corresponding":false},{"id":1714511,"name":"Lian-hui Liang","orcid":null,"position":15,"is_corresponding":false},{"id":1714513,"name":"Hui-xuan Xiao","orcid":null,"position":16,"is_corresponding":false},{"id":1714515,"name":"Zheng-qi Shi","orcid":null,"position":17,"is_corresponding":false},{"id":1714516,"name":"Xue-mei Hu","orcid":null,"position":18,"is_corresponding":false},{"id":1094466,"name":"Qian Li","orcid":"0009-0002-0336-4021","position":19,"is_corresponding":false},{"id":1714517,"name":"He-yong Chen","orcid":null,"position":20,"is_corresponding":false},{"id":1714518,"name":"Yong-jian Ke","orcid":null,"position":21,"is_corresponding":false},{"id":1714519,"name":"Wen-ying Luo","orcid":null,"position":22,"is_corresponding":false},{"id":1714520,"name":"Guan-jun Huang","orcid":null,"position":23,"is_corresponding":false},{"id":1714522,"name":"Jin-bo Huang","orcid":null,"position":24,"is_corresponding":false},{"id":749901,"name":"Ying Peng","orcid":"0000-0003-3937-5080","position":25,"is_corresponding":false},{"id":1714523,"name":"He-Ping Zheng","orcid":null,"position":26,"is_corresponding":false},{"id":674001,"name":"Yang Chen","orcid":"0009-0008-5752-1639","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Emerging epidemic of the predominant clusters of FC428-like Neisseria gonorrhoeae in Guangdong, China","abstract":"<h4>Objectives</h4>This study aimed to investigate the molecular characteristics of predominant epidemic clusters of FC428-like N. gonorrhoeae in Guangdong, China in 2022.<h4>Methods</h4>Minimum inhibitory concentrations (MICs) were determined for N. gonorrhoeae isolates collected from the Guangdong Gonococcal Antimicrobial Surveillance Program. N. gonorrhoeae multiantigen sequence typing (NG-MAST), antimicrobial resistance sequence typing (NG-STAR), multilocus sequence typing (MLST) sequence types (STs), and penA alleles were determined by whole-genome sequencing. The isolates were further characterised by phylogenetic analysis.<h4>Results</h4>A total of 537 N. gonorrhoeae isolates were analysed, molecular analysis revealed that 7.8% of the isolates carried penA 60.001 allele, which was highly resistant to ceftriaxone (88.1%) and cefixime (100.0%). The predominant STs in penA 60.001 isolates were MLST ST1903 (23,54.8%), ST7365 (11,26.2%), NG-STAR ST1143 (13,31.0%), ST233 (4,9.5%), ST1133 (4,9.5%), and NG-MAST ST22261 (10,23.8%). Among 537 isolates, of which 11.2% were resistant to ceftriaxone and 19.6% to cefixime. In western Guangdong, resistance to ceftriaxone and cefixime reached 17.3% and 26.9%, respectively. The most predominant types among ceftriaxone-resistant isolates are genetically closer to FC428 isolates, and differ from those among cefixime-resistant isolates. Phylogenetic analysis revealed that the Guangdong FC428-like isolates from 2021 to 2022 spread across the whole phylogenetic tree, but the majority were clustered within a distinct evolutionary clade.<h4>Conclusions</h4>FC428-like isolates in Guangdong formed a unique evolutionary clade with high cephalosporin resistance. These findings highlight the need to revise national gonorrhea treatment guidelines and prioritise the development of new antimicrobials.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40675487","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82104626","title":null},{"funder_name":"Guangzhou Municipal Science and Technology Project","grant_id":"202201000007","title":null},{"funder_name":"Zhejiang Traditional Chinese Medicine Administration","grant_id":"20242063","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.jgar.2025.07.005","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213716525001626?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213716525001626?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doaj.org/article/ca2b019f3e1449a88f37e25f1a61bd43","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Humans","Neisseria gonorrhoeae","Gonorrhea","Ceftriaxone","Anti-Bacterial Agents","Microbial Sensitivity Tests","Phylogeny","Adult","China","Female","Male","Young Adult","Epidemics","Multilocus Sequence Typing","Whole Genome Sequencing"],"keywords":["Drug resistance","Whole-genome Sequencing","Extended-spectrum Cephalosporins","Genomic Epidemiology","Pena 60.001","Fc428 Clones"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T22:24:41.723656Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}