{"doi":"10.1016/j.jgar.2024.12.016","title":"Clinical and genomic characterization of Klebsiella pneumoniae infections in Dhaka, Bangladesh","abstract":"BACKGROUND: Klebsiella pneumoniae (Kpn), a WHO priority pathogen with high rates of antimicrobial resistance (AMR), has emerged as a leading cause of hospital acquired pneumonia and neonatal sepsis. OBJECTIVE: We aimed to define the clinical characteristics of a cohort of patients with Kpn infection in Dhaka, Bangladesh and to perform phenotypic and genetic characterization of the associated isolates. METHODS: We retrospectively extracted clinical data about patients at Dhaka Medical College Hospital from whom Klebsiella spp was isolated from a clinical specimen collected between February and September 2022. We used standard microbiologic techniques to evaluate AMR and whole-genome sequencing (WGS) to assess dominant lineages, common capsular (K) and O-polysaccharide (O) antigen types, and AMR and virulence genes. RESULTS: Ninety-eight patients were included, with diagnoses of pneumonia (38/98, 39 %), wound infection (29/98, 31 %), urinary tract infection (29/98, 31 %) and bacteremia (2/98, 2 %). We tested isolates for susceptibility to eight classes of antibiotics. Of the 98 isolates, 41 % were multidrug resistant (MDR), 15 % were extensively drug resistant (XDR), and 16 % were pan-drug resistant (PDR). Three isolates (3 %) were resistant to polymyxin B. Outcome data were available for 46 patients; 4 patients (8 %) died from infections caused by PDR (n = 2), XDR (n = 1), and MDR isolates (n = 1). WGS revealed a high degree of genomic diversity, with multiple sequence types (STs), O-types and K-types represented; ST16:K81:OL101 and ST43:K30:O1 were the most prevalent. CONCLUSION: Our findings suggest alarming levels of AMR among Kpn isolates in Bangladesh and a critical need for improved treatment modalities and vaccine development.","journal":"Journal of Global Antimicrobial Resistance","year":2024,"id":451213,"datarank":0.26686273405729927,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.025447047192184186,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.025447047192184186,"corpus_percentile":41.56416802042237,"corpus_rank":7555,"citation_count":4,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5421,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1046802,"name":"Sushmita Sridhar","orcid":null,"position":1,"is_corresponding":false},{"id":1272213,"name":"Sanchita Kar","orcid":"0000-0003-1098-8449","position":2,"is_corresponding":false},{"id":1272214,"name":"Tanbir Habib","orcid":"0000-0001-6828-9283","position":3,"is_corresponding":false},{"id":1272673,"name":"Sharmin Akter Mukta","orcid":null,"position":4,"is_corresponding":false},{"id":1272674,"name":"Kasrina Azad","orcid":null,"position":5,"is_corresponding":false},{"id":1272215,"name":"N. 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Turbett","orcid":"0000-0002-3603-8110","position":14,"is_corresponding":false},{"id":1272219,"name":"SM Shamsuzzaman","orcid":"0000-0003-2886-8840","position":15,"is_corresponding":false},{"id":109068,"name":"Jason B. Harris","orcid":"0000-0003-3642-5126","position":16,"is_corresponding":false},{"id":352718,"name":"Firdausi Qadri","orcid":"0000-0001-8459-304X","position":17,"is_corresponding":false},{"id":62201,"name":"Regina C. 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