{"doi":"10.1016/j.jfma.2025.02.024","title":"Left atrial reservoir strain as a surrogate marker for atrial fibrillation burden in patients with non-valvular atrial fibrillation","abstract":"BACKGROUND: To evaluate the correlation between atrial fibrillation (AF) burden and two-dimensional LA (left atrium) longitudinal reservoir strain (LARS) to explore the potential clinical utility of this novel parameter in patients with AF. METHODS: This cross-sectional study was conducted at the cardiac electrophysiology clinic of a tertiary centre by consecutively enrolling patients with non-valvular AF. The AF burden was evaluated using 14-day patch-based electrocardiography and defined as the percentage of time spent in AF during a 14-day monitoring period. High and low AF burdens were defined based on the median 14-day AF burden. Echocardiographic measurements, including the longitudinal strain of the LA, were performed in all patients. RESULTS: Among 267 patients, LARS was successfully performed in 221 (age 63 ± 11 years, male 71%, paroxysmal AF 71%). After adjusting for age, diabetes mellitus, congestive heart failure, estimated glomerular filtration rate, low-density lipoprotein level, left ventricular ejection fraction, LA dimension, and LA volume in multivariable linear regression analysis, low LARS remained a significant predictor of AF burden in addition to N-terminal pro-B-type natriuretic peptide and sex. Receiver operating curve analysis demonstrated that the best cut-off value for LARS to predict high AF burden (above median 10.49%) was 21.5%, with 75% sensitivity and 83% specificity. CONCLUSION: LARS is associated with the AF burden in patients with AF. Further studies are needed to determine the role of routine LARS measurements in such patients.","journal":"Journal of the Formosan Medical Association","year":2025,"id":540478,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7275,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":395425,"name":"Yen‐Bin Liu","orcid":"0000-0003-0623-9146","position":1,"is_corresponding":false},{"id":1061352,"name":"Lian‐Yu Lin","orcid":"0000-0001-7505-6429","position":2,"is_corresponding":false},{"id":396437,"name":"Lian-Yu Lin","orcid":null,"position":3,"is_corresponding":false},{"id":395427,"name":"Hui‐Chun Huang","orcid":"0000-0003-1743-7850","position":4,"is_corresponding":false},{"id":1061353,"name":"Li‐Ting Ho","orcid":"0000-0003-2095-4410","position":5,"is_corresponding":false},{"id":1428219,"name":"Kuan‐Chih Huang","orcid":"0000-0001-7100-8091","position":6,"is_corresponding":false},{"id":258824,"name":"Ling‐Ping Lai","orcid":"0000-0002-9651-7420","position":7,"is_corresponding":false},{"id":395424,"name":"Wen‐Jone Chen","orcid":"0000-0002-2098-5922","position":8,"is_corresponding":false},{"id":1062040,"name":"Yi-Lwung Ho","orcid":null,"position":9,"is_corresponding":false},{"id":1305165,"name":"Lung‐Chun Lin","orcid":"0000-0002-7325-0823","position":10,"is_corresponding":false},{"id":395426,"name":"Chih‐Chieh Yu","orcid":"0000-0002-2136-2444","position":12,"is_corresponding":false},{"id":1305166,"name":"An‐Li Yu","orcid":"0000-0001-5512-9395","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:52:38.861025Z","pmid":"40000350","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}