{"doi":"10.1016/j.jff.2024.106096","title":"Omega-3 fatty acid supplementation attenuates intestinal mucositis and tumor growth in a murine model of breast cancer","abstract":"The potential use of Omega-3 fatty acid for its anti-inflammatory properties has been proposed to alleviate the side effects of cancer therapeutics. Fifty female BALB/c mice were randomly assigned to five treatment groups. Mice were injected with Murine 4 T1 breast cancer cells, and 5-fluorouracil (5-FU) to induce mucositis. The mice were provided control or chow supplemented with Omega-3 fatty acid (fish oil with 15 % EPA and 7 % DHA, respectively). Our results showed that, the use of Omega-3 prevented intestinal mucositis by reducing intestinal permeability and restoring histological parameters. Additionally, Omega-3 supplementation enhanced the antineoplastic effect of 5-FU, as evidenced by a greater reduction in tumor growth compared to the other groups. Furthermore, the combined administration of 5-FU and Omega-3 significantly reduced the formation of lung metastasis. Collectively, these findings suggest that Omega-3 supplementation, particularly in conjunction with 5-FU, may contribute to the treatment of cancer by decreasing induced intestinal mucositis.","journal":"Journal of Functional Foods","year":2024,"id":457320,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1282630,"name":"Luísa Martins Trindade","orcid":"0000-0002-8367-0557","position":1,"is_corresponding":false},{"id":1282631,"name":"Amanda Dias Borges","orcid":"0000-0001-9332-4888","position":2,"is_corresponding":false},{"id":1282632,"name":"Paola Caroline Lacerda Leocádio","orcid":"0000-0002-1483-4466","position":3,"is_corresponding":false},{"id":904238,"name":"Juliana de Oliveira Silva","orcid":"0000-0002-6489-8935","position":4,"is_corresponding":false},{"id":877258,"name":"Renata Salgado Fernandes","orcid":"0000-0002-7720-6395","position":5,"is_corresponding":false},{"id":1282961,"name":"Jaqueline Isaura Alvarez Leite","orcid":null,"position":6,"is_corresponding":false},{"id":516112,"name":"Geovanni Dantas Cassali","orcid":"0000-0002-5650-6743","position":7,"is_corresponding":false},{"id":516111,"name":"Diego Carlos dos Reis","orcid":"0000-0002-9676-7745","position":8,"is_corresponding":false},{"id":1282633,"name":"Tatiani Uceli Maioli","orcid":"0000-0002-7538-3208","position":9,"is_corresponding":false},{"id":1282634,"name":"Valbert Nascimento Cardoso","orcid":"0000-0001-7597-9602","position":10,"is_corresponding":false},{"id":426398,"name":"Danyelle M. Townsend","orcid":"0000-0003-4679-1891","position":11,"is_corresponding":false},{"id":646315,"name":"André Luís Branco de Barros","orcid":"0000-0002-7641-6585","position":12,"is_corresponding":false},{"id":1282635,"name":"Simone de Vasconcelos Generoso","orcid":"0000-0001-6413-8031","position":13,"is_corresponding":false},{"id":1282960,"name":"Aline Luiza A. Souza","orcid":null,"position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T02:03:37.136946Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}