{"doi":"10.1016/j.jff.2015.09.060","title":"Anti-adipogenic effect of erucin in early stage of adipogenesis by regulating Ras activity in 3T3-L1 preadipocytes","abstract":null,"journal":"Journal of Functional Foods","year":2015,"id":675470,"datarank":1.1237069952443992,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.6600506272406517,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.6600506272406517,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":19,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1764874,"name":"Sang Gwon Seo","orcid":null,"position":1,"is_corresponding":false},{"id":1764875,"name":"Hee Yang","orcid":null,"position":2,"is_corresponding":false},{"id":1764876,"name":"Jae Gak Yu","orcid":null,"position":3,"is_corresponding":false},{"id":1764877,"name":"Su Jin Suk","orcid":null,"position":4,"is_corresponding":false},{"id":1543575,"name":"Eun Sun Jung","orcid":null,"position":5,"is_corresponding":false},{"id":1764880,"name":"Hae Ji","orcid":null,"position":6,"is_corresponding":false},{"id":1756571,"name":"Jung Yeon Kwon","orcid":null,"position":7,"is_corresponding":false},{"id":1182974,"name":"Hyong Joo Lee","orcid":null,"position":8,"is_corresponding":false},{"id":202517,"name":"Ki Won Lee","orcid":null,"position":9,"is_corresponding":false},{"id":1764873,"name":"Seung Young Chae","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anti-adipogenic effect of erucin in early stage of adipogenesis by regulating Ras activity in 3T3-L1 preadipocytes","abstract":"Erucin is a natural isothiocyanate found in rocket salad and broccoli which are believed to have health benefits including weight control effect and used as a functional food globally. Though anti-cancer effect of erucin has been intensively studied, anti-obesity effect of erucin and its molecular mechanisms have not yet been reported. In this study, we investigated anti-adipogenic effect of erucin in 3T3-L1 preadipocytes and its underlying molecular mechanisms. Erucin inhibited adipogenesis of 3T3-L1 preadipocytes and reduced adipogenic gene expressions. This anti-adipogenic activity of erucin was most effective at early stage of adipogenesis including mitotic clonal expansion (MCE). Fluorescence-activated cell sorter (FACS) analysis and trypan blue assay results showed that erucin induced G1/S arrest and inhibited cell proliferation at MCE stage. Western blot analysis results showed that erucin inhibited extracellular signal-regulated kinase (ERK) signaling pathway by blocking Ras activity. Taken together, these results indicated that erucin inhibits adipogenesis of 3T3-L1 preadipocytes by blocking Ras activity at early stage of adipogenesis.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W1856551424","authors":[],"funders":[{"funder_name":"Bio-industry Technology Development Program","grant_id":"514004","title":null}],"total_grants":1,"fwci":0.822,"citation_percentile":0.73454387,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S1756464615004922/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S1756464615004922/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1756464615004922?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1756464615004922?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jff.2015.09.060","host_type":"journal"},{"url":"https://doaj.org/article/145ca787247848b5a10a021ba9af214a","host_type":"repository"}],"fields_of_study":["Adipokines, Inflammation, and Metabolic Diseases","Adipose Tissue and Metabolism","Sirtuins and Resveratrol in Medicine"],"mesh_terms":[],"keywords":["Adipogenesis","3T3-L1","MAPK/ERK pathway","Chemistry","Cell biology","Downregulation and upregulation","Western blot","Internal medicine","Endocrinology","Signal transduction","Biology","Adipose tissue","Biochemistry","Gene","Medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T00:56:21.040237Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}