{"doi":"10.1016/j.jep.2024.119030","title":"Artemisia capillaris Thunb. Water extract alleviates metabolic dysfunction-associated Steatotic liver disease Disease by inhibiting miR-34a-5p to activate Sirt1-mediated hepatic lipid metabolism","abstract":null,"journal":"Journal of Ethnopharmacology","year":2025,"id":647217,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1411019,"name":"Xiao Xiao","orcid":"0000-0001-5124-0985","position":1,"is_corresponding":false},{"id":597333,"name":"Miao Chen","orcid":"0000-0001-5165-9823","position":2,"is_corresponding":false},{"id":113649,"name":"Yi Guo","orcid":null,"position":3,"is_corresponding":false},{"id":1686099,"name":"Weiting Han","orcid":null,"position":4,"is_corresponding":false},{"id":1686100,"name":"Yahong Min","orcid":null,"position":5,"is_corresponding":false},{"id":873747,"name":"Xiaowen Jiang","orcid":"0000-0003-1618-4265","position":6,"is_corresponding":false},{"id":1686101,"name":"Wenhui Yu","orcid":"0000-0002-3744-4575","position":7,"is_corresponding":false},{"id":903062,"name":"Meng Liang","orcid":"0000-0003-0916-520X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Artemisia capillaris Thunb. Water extract alleviates metabolic dysfunction-associated Steatotic liver disease Disease by inhibiting miR-34a-5p to activate Sirt1-mediated hepatic lipid metabolism","abstract":"<h4>Ethnopharmacological relevance</h4>Artemisia capillaris Thunb. (ACT) is a plant in the Asteraceae family. Its traditional effects are to clear away dampness and heat, promote gallbladder and reduce jaundice. Traditional Chinese medicine believes that MASLD is a damp-heat syndrome. The group's previous study showed that Artemisia capillaris Thunb. Water Extract (ACTE) has an improved effect on MASLD.<h4>Aim of the study and methods</h4>In order to further understand its mechanism of action, this study established a mouse MASLD model and a HepG2 cell lipid droplet model, combined small RNA sequencing and miRNA transfection experiments, to explore the mechanism of ACTE to improve MASLD by modulating miRNA-targeted mRNA. Non-targeted metabolomics method was used to detect and analyze ACTE.<h4>Results</h4>This study screened miR-34a-5p and confirmed its target mRNA-Sirtuin 1 (Sirt1). MASLD induced high expression of miR-34a-5p and low expression of Sirt1, and ACE reversed these changes. When overexpressing miR-34a-5p or knocking down Sirt1, the effect of ACE in reducing PO (palmitic acid and oleic acid complex)-induced lipid accumulation in HepG2 cells was attenuated. ACTE reduces the expression of FASN, SCD1, ACC, and SREBP-1c, promotes the expression of CPT-1 and HSL, thereby reducing lipid accumulation.<h4>Conclusions</h4>ACTE activates Sirt1 by inhibiting the expression of miR-34a-5p, thereby reducing liver lipid accumulation and improving HFD-induced MASLD. These findings highlight the potential of ACTE in reducing weight, controlling obesity, and improving lipid metabolism disorders.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39515682","pmcid":null,"openalex_id":"https://openalex.org/W4404117946","authors":[],"funders":[],"total_grants":0,"fwci":3.7807,"citation_percentile":0.94310789,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":7}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0378874124013291?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0378874124013291?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jep.2024.119030","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39515682","host_type":"repository"}],"fields_of_study":["Liver Disease Diagnosis and Treatment","Sirtuins and Resveratrol in Medicine","Drug-Induced Hepatotoxicity and Protection","MicroRNAs","Artemisia","Animals","Lipid Metabolism","Humans","Sirtuin 1","Hep G2 Cells","Plant Extracts","Male","Mice","Liver","Mice, Inbred C57BL","Fatty Liver","Water","Disease Models, Animal","Non-alcoholic Fatty Liver Disease"],"mesh_terms":["Animals","Disease Models, Animal","Fatty Liver","Humans","Liver","Male","Mice, Inbred C57BL","Plant Extracts","Water","Artemisia","MicroRNAs","Lipid Metabolism","Mice","Sirtuin 1","Hep G2 Cells","Non-alcoholic Fatty Liver Disease"],"keywords":["Lipid metabolism","Disease","Metabolism","Medicine","Lipid Metabolism Disorder","Liver disease","Fatty liver","Pharmacology","Steatosis","Biochemistry","Chemistry","Internal medicine","Cholesterol","Blood lipids","Lipid accumulation","SIRT1","Artemisia Capillaris Thunb","Mir-34a-5p","Masld"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T17:25:11.952319Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}