{"doi":"10.1016/j.jdin.2024.04.010","title":"Incidence and mortality trends of primary cutaneous melanoma: A 50-year Rochester Epidemiologic Project study","abstract":"Background National cancer reporting-based registry data, although robust, lacks granularity for incidence trends. Expert opinion remains conflicted regarding the possibility of melanoma overdiagnosis in the context of rising incidence without a corresponding rise in mortality. Objective To characterize 10- and 50-year trends in melanoma incidence and mortality. Methods Multicenter, population-based epidemiologic study utilizing the Rochester Epidemiology Project for Olmsted County, Minnesota residents diagnosed with melanoma from 01/01/1970 to 12/21/2020. Age- and sex-adjusted incidence and disease-specific mortality are calculated. Results Two thousand three hundred ten primary cutaneous melanomas were identified. Current age- and sex-adjusted incidence rates increased 11.1-fold since 1970s ( P < .001). Over the last decade, there is an overall 1.21-fold ( P < .002) increase, with a 1.36-fold increase ( P < .002) among females and no significant increase among males (1.09-fold increase, P < .329). Melanoma-specific mortality decreased from 26.7% in 1970s to 1.5% in 2010s, with a hazard ratio (HR) reduction of 0.73 ( P < .001) per 5-year period. Increased mortality was associated with Breslow thickness (HR 1.35, P < .001), age at diagnosis (HR 1.13, P = .001) left anatomic site (HR 1.98, P = .016), and nodular histogenic subtype (HR 3.08, P < .001). Limitations Retrospective nature and focused geographic investigation. Conclusion Melanoma incidence has continued to increase over the past decade, most significantly in females aged 40+. Trend variations among age and sex cohorts suggests external factors beyond overdiagnosis may be responsible. Disease-specific mortality of melanoma continues to decrease over the last 50 years.","journal":"JAAD International","year":2024,"id":438338,"datarank":0.46005788449359586,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.10037359357384021,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.10037359357384021,"corpus_percentile":58.79167633635028,"corpus_rank":5328,"citation_count":10,"citer_count":10,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5757,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1128476,"name":"Elliott H. Campbell","orcid":"0000-0002-4451-6135","position":1,"is_corresponding":false},{"id":1147678,"name":"Sydney L. Proffer","orcid":"0000-0002-9696-5418","position":2,"is_corresponding":false},{"id":314103,"name":"Olivia M. Crum","orcid":"0000-0001-5061-7453","position":3,"is_corresponding":false},{"id":908081,"name":"Austin Todd","orcid":"0000-0002-6115-4770","position":4,"is_corresponding":false},{"id":1128478,"name":"Lawrence E. Gibson","orcid":"0000-0002-3918-3962","position":5,"is_corresponding":false},{"id":790471,"name":"Jerry D. Brewer","orcid":null,"position":6,"is_corresponding":false},{"id":1128479,"name":"Addison M. Demer","orcid":"0000-0003-3764-7361","position":7,"is_corresponding":false},{"id":1128477,"name":"Jacob P. Reinhart","orcid":"0000-0001-7131-3627","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:00:38.888629Z","pmid":"38957842","pmcid":"PMC11217686","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}