{"doi":"10.1016/j.jdcr.2020.12.024","title":"Nanotomography of lesional skin using electron microscopy reveals cytosolic release of nuclear DNA in psoriasis","abstract":"Psoriasis is a common, chronic inflammatory skin disease associated with thick, scaly erythematous plaques on the extensor and flexor surfaces of the skin. Psoriasis is linked to cardiometabolic comorbidities leading to decreased life expectancy,1 and although the underlying mechanisms are not yet fully understood, inflammation is a key driver of these associations. Normally, DNA is confined to the nucleus and the mitochondria. In disease, DNA is released to the cytosol2,3 and is an important danger-associated molecular pattern in keratinocytes, which is accelerated in the presence of psoriasis-associated proinflammatory cytokines.","journal":"JAAD Case Reports","year":2021,"id":185951,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281793,"name":"Yvonne Baumer","orcid":"0000-0001-7400-0773","position":1,"is_corresponding":false},{"id":506221,"name":"Erin Stempinski","orcid":"0000-0001-7818-5584","position":2,"is_corresponding":false},{"id":295129,"name":"Justin Rodante","orcid":"0000-0002-2435-7747","position":3,"is_corresponding":false},{"id":281794,"name":"Tiffany M. Powell‐Wiley","orcid":"0000-0001-9488-4131","position":4,"is_corresponding":false},{"id":235793,"name":"Amit K. Dey","orcid":"0000-0002-7750-910X","position":5,"is_corresponding":false},{"id":284872,"name":"Saeko Nakajima","orcid":"0000-0003-0831-1447","position":6,"is_corresponding":false},{"id":284638,"name":"Martin P. Playford","orcid":"0000-0002-5571-7266","position":7,"is_corresponding":false},{"id":109646,"name":"Christopher K. E. Bleck","orcid":"0000-0003-1029-3444","position":8,"is_corresponding":false},{"id":233337,"name":"Nehal N. Mehta","orcid":"0000-0003-4939-5130","position":9,"is_corresponding":false},{"id":236476,"name":"Eric Lindberg","orcid":"0000-0002-4258-5583","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-18T23:48:42.632147Z","pmid":"33598517","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}