{"doi":"10.1016/j.jcv.2007.10.006","title":"Donor and recipient CMV serostatus and antigenemia after renal transplantation: An analysis of 486 patients","abstract":null,"journal":"Journal of Clinical Virology","year":2008,"id":595612,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1525228,"name":"John Hafferty","orcid":null,"position":1,"is_corresponding":false},{"id":1525229,"name":"Lee Fulton","orcid":null,"position":2,"is_corresponding":false},{"id":1525230,"name":"Peter Friend","orcid":null,"position":3,"is_corresponding":false},{"id":1525231,"name":"Andrea Devaney","orcid":null,"position":4,"is_corresponding":false},{"id":1375661,"name":"Justin Loke","orcid":"0000-0002-0725-069X","position":5,"is_corresponding":false},{"id":1525232,"name":"Ken I. Welsh","orcid":null,"position":6,"is_corresponding":false},{"id":1020200,"name":"Ashok Handa","orcid":"0000-0001-7888-7180","position":7,"is_corresponding":false},{"id":106117,"name":"Paul Klenerman","orcid":"0000-0003-4307-9161","position":8,"is_corresponding":false},{"id":293018,"name":"David Hughes","orcid":"0000-0002-4194-2147","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Donor and recipient CMV serostatus and antigenemia after renal transplantation: An analysis of 486 patients","abstract":"BACKGROUND: Cytomegalovirus infection in renal transplant recipients is a major clinical problem, with both short and long term sequelae. Infection can occur as a result of reactivation of latent virus or new infection from donor tissues. The impact of donor and recipient serostatus on viremia is well recognised, with seronegative recipients at greatest risk after transplantation of an organ from a seropositive donor. However, the impact of grafting such organs into seropositive recipients is less clear. OBJECTIVES: To assess the impact of recipient serostatus on the risk of CMV antigenemia in a large renal transplant cohort. STUDY DESIGN: We prospectively quantified CMV antigenemia over time in a cohort of 486 recipients. We analysed the antigenemia status according to donor and recipient serostatus. RESULTS: Antigenemia was most common in seronegative recipients of organs from seropositive donors (D+/R-). Nevertheless, we observed that even in CMV seropositive recipients, the impact of donor serostatus on CMV antigenemia is still substantial (p=0.006; OR=2.2). CONCLUSIONS: In this large study, donor serostatus clearly plays a significant role in determining CMV risk, even in seropositive recipients.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18032098","pmcid":null,"openalex_id":"https://openalex.org/W1994465650","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":2,"fwci":1.3108,"citation_percentile":0.80104374,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":3},{"year":2014,"count":6},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jcv.2007.10.006","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jcv.2007.10.006","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1386653207003691?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1386653207003691?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18032098","host_type":"repository"},{"url":"https://ora.ox.ac.uk/objects/uuid:7fbf1bc5-d0d2-48af-a3a7-f3dff31347df","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2581120","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.jcv.2007.10.006","host_type":""},{"url":"https://dx.doi.org/10.1016/j.jcv.2007.10.006","host_type":""}],"fields_of_study":["Cytomegalovirus and herpesvirus research","HIV Research and Treatment","Hepatitis Viruses Studies and Epidemiology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Antibodies, Viral","Cytomegalovirus","Cytomegalovirus Infections","Humans","Kidney Transplantation","Phosphoproteins","Tissue Donors","Viral Matrix Proteins","Virus Activation"],"mesh_terms":["Antibodies, Viral","Cytomegalovirus Infections","Cytomegalovirus","Humans","Phosphoproteins","Tissue Donors","Viral Matrix Proteins","Virus Activation","Kidney Transplantation"],"keywords":["Serostatus","Medicine","Viremia","Transplantation","Cytomegalovirus","Cohort","Immunology","Kidney transplantation","Human cytomegalovirus","Internal medicine","Viral disease","Herpesviridae","Virus","Viral load","CMV","Transplant","Kidney","Reactivation","Antibodies, Viral","Phosphoproteins","Article","Tissue Donors","Viral Matrix Proteins","Infectious Diseases","Superinfection","Virology","Cytomegalovirus Infections","Humans","Virus Activation"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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