{"doi":"10.1016/j.jctube.2024.100504","title":"Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India","abstract":"Background: Pregnancy and HIV affect CD4+ T lymphocytes and impact performance of QuantiFERON-TB Gold (QFT). We compared the results of QFT with QuantiFERON-TB Gold Plus (QFT-Plus), which also measures CD8+ responses to TB antigens, during pregnancy and postpartum. Methods: We screened 516 pregnant women for TB infection (TBI) with IGRA. From 165 IGRA + pregnant women, QFT vs QFT-Plus results were compared at delivery and postpartum. Longitudinal changes in QFT-Plus were assessed in 74 pregnant women who received QFT-Plus testing at pregnancy, delivery, and postpartum. Results: Through cross-sectional analysis of the IGRA + cohort, QFT-Plus showed higher positivity than QFT (80 % vs 65 %, p = 0.04) at delivery but no difference postpartum. Among 35 women with HIV, QFT-Plus returned more positive results than QFT at delivery and postpartum (76 % vs 47 %, p = 0.08; 90 % vs 80 %, p = 0.54), though not statistically significant. Longitudinally, QFT-Plus positivity by TB1 or TB2 was highest antepartum vs. delivery and postpartum (74 % vs. 58 % vs. 62 %; p = 0.09) and performed better than TB1 alone (100 % vs 90 %, p = 0.04) in women without HIV but not in women with HIV. Conclusions: Performance of QFT-Plus was consistent across pregnancy, including at delivery when QFT positivity is lower. QFT-Plus may enhance antenatal TBI detection among pregnant women.","journal":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","year":2024,"id":506973,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":515936,"name":"Mallika Alexander","orcid":"0000-0001-9332-7915","position":1,"is_corresponding":false},{"id":472627,"name":"Ramesh Bhosale","orcid":null,"position":2,"is_corresponding":false},{"id":327693,"name":"Divyashri Jain","orcid":null,"position":3,"is_corresponding":false},{"id":515939,"name":"Prasad Deshpande","orcid":"0000-0001-6389-533X","position":4,"is_corresponding":false},{"id":297871,"name":"Emily Shira Gitlin","orcid":"0009-0004-7096-7759","position":5,"is_corresponding":false},{"id":1358685,"name":"Arthi Vaidyanathan","orcid":null,"position":6,"is_corresponding":false},{"id":743815,"name":"Andrea Chalem","orcid":"0000-0002-2959-0070","position":7,"is_corresponding":false},{"id":376085,"name":"Shilpa Naik","orcid":"0000-0002-9296-0353","position":8,"is_corresponding":false},{"id":326403,"name":"Nikhil Gupte","orcid":"0000-0002-6688-2478","position":9,"is_corresponding":false},{"id":1358361,"name":"Neelu Nawani","orcid":"0000-0002-9979-751X","position":10,"is_corresponding":false},{"id":326405,"name":"Amita Gupta","orcid":"0000-0001-7036-2718","position":11,"is_corresponding":false},{"id":366696,"name":"Jyoti S. Mathad","orcid":"0000-0001-9487-7775","position":12,"is_corresponding":false},{"id":326396,"name":"Vandana Kulkarni","orcid":"0000-0002-3488-2692","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:10:58.484528Z","pmid":"39758562","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}