{"doi":"10.1016/j.jconrel.2026.114647","title":"Dual-biomimetic Nanodecoys reprogram cardiac macrophages by suppressing STING signaling for heart repair","abstract":null,"journal":"Journal of Controlled Release","year":2026,"id":645068,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1161346,"name":"Ruobing Li","orcid":"0000-0002-6526-6497","position":1,"is_corresponding":false},{"id":1679457,"name":"Jinjin Ni","orcid":null,"position":2,"is_corresponding":false},{"id":1679458,"name":"Duanbin Li","orcid":null,"position":3,"is_corresponding":false},{"id":1679459,"name":"Mei Hua Ting","orcid":null,"position":4,"is_corresponding":false},{"id":345008,"name":"Kai Ma","orcid":"0000-0003-4415-6894","position":5,"is_corresponding":false},{"id":1490739,"name":"Guosheng Fu","orcid":null,"position":6,"is_corresponding":false},{"id":57265,"name":"Junbo Ge","orcid":"0000-0002-9360-7332","position":7,"is_corresponding":false},{"id":1679460,"name":"Shenggang Zhao","orcid":null,"position":8,"is_corresponding":false},{"id":1325561,"name":"Wenbin Zhang","orcid":"0000-0002-4927-9570","position":9,"is_corresponding":false},{"id":921484,"name":"Ning Zhang","orcid":"0000-0003-2095-5261","position":10,"is_corresponding":false},{"id":762987,"name":"Xianglan Liu","orcid":"0000-0001-8870-8174","position":11,"is_corresponding":false},{"id":1419920,"name":"Peng Wang","orcid":"0000-0002-7013-2039","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dual-biomimetic Nanodecoys reprogram cardiac macrophages by suppressing STING signaling for heart repair","abstract":"Myocardial infarction (MI) initiates sterile inflammation through the release of cytosolic DNA from necrotic cardiomyocytes, which aberrantly activates the cGAS-STING pathway in infiltrating macrophages and drives their polarization toward a pro-inflammatory M1 phenotype. Although the immunosuppressive oligodeoxynucleotide A151 can antagonize cGAS activation, its therapeutic utility is limited by enzymatic instability and inefficient cellular delivery. Here, we report a dual-biomimetic nanodecoy (A151@APPL) that integrates platelet membrane vesicles for infarct-specific targeting with arginine-modified phosphatidylserine lipids to promote macrophage uptake and enable nitric oxide-driven propulsion in redox-enriched tissue. This construct achieves efficient cytosolic delivery of A151 to lesional macrophages, suppressing the cGAS-STING axis, reducing pro-inflammatory cytokine expression, and reprogramming macrophages toward a reparative M2-like state. In a murine MI model, A151@APPL treatment attenuated ventricular inflammation, limited fibrotic remodeling, and restored cardiac performance. These findings establish a context-responsive delivery strategy that selectively modulates innate immune signaling and promotes cardiac repair following ischemic injury.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41565184","pmcid":null,"openalex_id":"https://openalex.org/W7124871234","authors":[],"funders":[{"funder_name":"Natural Science Foundation of Zhejiang Province","grant_id":"LQ24H020005","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82270262","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82100421","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82300565","title":null},{"funder_name":"Medical Science and Technology Project of Zhejiang Province","grant_id":"2024KY108","title":null}],"total_grants":5,"fwci":26.7209,"citation_percentile":0.99351202,"influential_citations":0,"citation_trend":[{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.jconrel.2026.114647","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jconrel.2026.114647","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168365926000489?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168365926000489?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41565184","host_type":"repository"}],"fields_of_study":["Cardiac Fibrosis and Remodeling","interferon and immune responses","Immune cells in cancer","Animals","Macrophages","cGAS-STING Signaling Pathway","Mice, Inbred C57BL","Male","Myocardial Infarction","Oligodeoxyribonucleotides","STING Protein","Signal Transduction","Mice","Membrane Proteins","Biomimetic Materials","Nanoparticles","Myocardium"],"mesh_terms":["cGAS-STING Signaling Pathway","STING Protein","Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase","Animals","Humans","Macrophages","Male","Membrane Proteins","Mice, Inbred C57BL","Myocardial Infarction","Myocardium","Nucleotidyltransferases","Oligodeoxyribonucleotides","Signal Transduction","Biomimetic Materials","Mice","Nanoparticles"],"keywords":["Inflammation","Macrophage polarization","Macrophage","Microvesicles","Phosphatidylserine","Immune system","Cytokine","Innate immune system","Reprogramming","Myocardial infarction","Biomimetic","Cgas-sting","Odn A151","Nanodecoy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T02:46:33.350058Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}