{"doi":"10.1016/j.jconrel.2025.113620","title":"Engineered dendritic cells-derived extracellular vesicles for cancer immunotherapy","abstract":null,"journal":"Journal of Controlled Release","year":2025,"id":620542,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1601992,"name":"Sofia Torres Quintas","orcid":null,"position":1,"is_corresponding":false},{"id":784525,"name":"Bruno Sarmento","orcid":"0000-0001-5763-7553","position":2,"is_corresponding":false},{"id":226803,"name":"Olivier De Wever","orcid":"0000-0002-5453-760X","position":3,"is_corresponding":false},{"id":644097,"name":"Flávia Castro","orcid":"0000-0002-2273-2806","position":4,"is_corresponding":false},{"id":1601990,"name":"Margarida Oliveira Coelho","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Engineered dendritic cells-derived extracellular vesicles for cancer immunotherapy","abstract":"Extracellular vesicles (EVs) have emerged as a cell-free therapeutic approach, garnering increasing attention for their potential to enhance the safety and efficacy of immunotherapy. This interest is primarily driven by the biocompatibility and cell/tissue tropism inherent to EVs, but also due to their reconfigurable content. This, termed as cargo, may comprise bioactive molecules as proteins, lipids, and nucleic acids that play a pivotal role in mediating intercellular communication. In particular, dendritic cells-derived extracellular vesicles (DC-EVs) facilitate the transfer of critical components, like antigens and immune-regulatory factors, and due to the expression of major histocompatibility complexes and co-stimulatory molecules on their surface can activate T cells, thereby modulating the immune response. Additionally, DC-EVs can be engineered to transport tumor-specific antigens, cytokines, or other agents in order to strength their immunotherapeutic potential, and even be used in vaccines formulation. In this review, the latest advancements in engineering DC-EVs to improve their immunotherapeutic potential is discussed in detail, while also addressing current challenges associated with DC-EVs therapies.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40088976","pmcid":null,"openalex_id":"https://openalex.org/W4408394714","authors":[],"funders":[{"funder_name":"Foundation for Science and Technology","grant_id":"PTDC/ MED-ONC/4165/2021","title":null}],"total_grants":1,"fwci":6.1055,"citation_percentile":0.97052161,"influential_citations":0,"citation_trend":[{"year":2025,"count":8},{"year":2026,"count":7}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1016/j.jconrel.2025.113620","host_type":"journal"},{"url":"https://doi.org/10.1016/j.jconrel.2025.113620","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168365925002378?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168365925002378?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40088976","host_type":"repository"},{"url":"https://biblio.ugent.be/publication/01JY16EEAQRW72TJ5409TJDDK7","host_type":"repository"},{"url":"https://biblio.ugent.be/publication/01JY16EEAQRW72TJ5409TJDDK7/file/01JY16GWQD3BNNV4EHDC7ECX4Y.pdf","host_type":"repository"}],"fields_of_study":["Extracellular vesicles in disease","Immunotherapy and Immune Responses","RNA Interference and Gene Delivery"],"mesh_terms":["Extracellular Vesicles","Animals","Dendritic Cells","Humans","Immunotherapy","Neoplasms","Cancer Vaccines"],"keywords":["Extracellular vesicles","Cancer immunotherapy","Immunotherapy","Vesicle","Chemistry","Dendritic cell","Microvesicles","Cell biology","Biology","Immune system","Immunology","Biochemistry","Membrane","Vaccines","Immunomodulation","Dendritic cells","Extracellular Vesicles Engineering"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T11:23:03.293027Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}