{"doi":"10.1016/j.jconrel.2019.04.023","title":"Characterizing the protein corona of sub-10 nm nanoparticles","abstract":null,"journal":"Journal of Controlled Release","year":2019,"id":623483,"datarank":1.9137072328848308,"base_score":4.02535169073515,"endowment":4.02535169073515,"self_citation_contribution":0.6038027536102726,"citation_network_contribution":1.3099044792745582,"self_endowment_contribution":0.6038027536102726,"citer_contribution":1.3099044792745582,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":55,"citers_with_citation_signal":50,"citers_with_endowment":50,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":860655,"name":"Yuwei Zhang","orcid":"0000-0002-7855-0710","position":1,"is_corresponding":false},{"id":1611328,"name":"Jamie L.Y. Wu","orcid":null,"position":2,"is_corresponding":false},{"id":1385801,"name":"Ben Ouyang","orcid":"0000-0003-1331-7093","position":3,"is_corresponding":false},{"id":1611329,"name":"Seiichi Ohta","orcid":null,"position":4,"is_corresponding":false},{"id":1611330,"name":"Warren C.W. Chan","orcid":null,"position":5,"is_corresponding":false},{"id":1611327,"name":"Dylan Glancy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Characterizing the protein corona of sub-10 nm nanoparticles","abstract":"Studies into the interactions of serum proteins with nanoparticles are typically performed using nanoparticles that are larger than the size of proteins. Due to this size discrepancy, adsorbed proteins are commonly depicted as a globular structure surrounding a nanoparticle. Here, we asked how we should view nanoparticle-protein complexes when the nanoparticles are of similar size or smaller than the proteins with which they interact. We showed that nanoparticles can serve as a cargo on a protein rather than as a carrier of the protein in a size-dependent manner. This can occur when nanoparticles are below 10 nm in diameter. We discovered that when the nanoparticle is a cargo on the protein, the binding of the protein to the receptor target is minimally affected in contrast to the nanoparticle serving as a carrier. Our study should change how we view and describe nanoparticle-protein complexes when the nanoparticles involved are equal in size or smaller than proteins.","is_dataset_classified":null,"base_score":4.02535169073515,"endowment":4.02535169073515,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31004667","pmcid":null,"openalex_id":"https://openalex.org/W2939008797","authors":[],"funders":[{"funder_name":"Canadian Cancer Society","grant_id":"705185-1","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"FDN159932","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP-130143","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"2015-0639","title":null},{"funder_name":"Canadian Research Chairs Program","grant_id":"950-223824","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":6,"fwci":1.8497,"citation_percentile":0.83537046,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":8},{"year":2021,"count":10},{"year":2022,"count":4},{"year":2023,"count":14},{"year":2024,"count":6},{"year":2025,"count":10},{"year":2026,"count":2}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0168365919302238?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168365919302238?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jconrel.2019.04.023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31004667","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.jconrel.2019.04.023","host_type":""}],"fields_of_study":["Nanoparticle-Based Drug Delivery","Polymer Surface Interaction Studies","Protein Interaction Studies and Fluorescence Analysis","0301 basic medicine","03 medical and health sciences","01 natural sciences","0104 chemical sciences","Blood Proteins","Humans","Nanoparticles","Particle Size","Protein Binding","Protein Corona","Serum Albumin, Bovine"],"mesh_terms":["Protein Corona","Blood Proteins","Humans","Particle Size","Protein Binding","Serum Albumin, Bovine","Nanoparticles"],"keywords":["Nanoparticle","Globular protein","Biophysics","Chemistry","Nanotechnology","Materials science","Crystallography","Biology","Carrier","Nanomedicine","Protein Corona","Ultrasmall Nanoparticles","Cargo","Humans","Nanoparticles","Serum Albumin, Bovine","Blood Proteins","Particle Size","Protein Binding"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T00:03:37.580490Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}