{"doi":"10.1016/j.jcms.2017.02.004","title":"Preliminary research on DNA methylation changes during murine palatogenesis induced by TCDD","abstract":null,"journal":"Journal of Cranio-Maxillofacial Surgery","year":2017,"id":47313,"datarank":1.0196374748655794,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.5559811068618319,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.5559811068618319,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":20,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":218743,"name":"Xin-gang Yuan","orcid":null,"position":1,"is_corresponding":false},{"id":218744,"name":"Cui-ping Liu","orcid":null,"position":2,"is_corresponding":false},{"id":218745,"name":"Sha-na Zhai","orcid":null,"position":3,"is_corresponding":false},{"id":218746,"name":"Ding-wen Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":218747,"name":"Yue-xian Fu","orcid":null,"position":5,"is_corresponding":false},{"id":34354,"name":"Chen Wang","orcid":"0000-0003-2638-3081","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Preliminary research on DNA methylation changes during murine palatogenesis induced by TCDD","abstract":"2,3,7,8-Tetrachlrodibenzo-p-dioxin (TCDD) has been shown to induce cleft palate through growth factor and receptor expression changes during palatogenesis. DNA methylation is an important epigenetic modification that can regulate gene expressions and may be involved in TCDD-induced cleft palate. In this study, we investigated the effects of TCDD on the global and CpG DNA methylation status and the expression levels of DNA methyltransferases (Dnmts) in palate tissue of fetal mice. Pregnant C57BL/6J mice were administered with corn oil or TCDD 28 μg/kg at gestation day 10.5(GD10.5), and sacrificed at GD13.5, 14.5, 15.5. Fetal palates were collected for molecular analysis. Global DNA methylation status was detected by Methylamp™ Global DNA Methylation Quantification Ultra Kit. The expression of DNA methyltransferases were examined by quantitative real-time PCR(q-PCR). Methylation Specific PCR (MSP) was performed to analyze CpG methylation status of Dnmts. We found that the global DNA methylation level and the expression of Dnmt3a were higher at GD13.5 in the TCDD group. The methylation level of CpG site 2 in the promoter region of Dnmt3a in the control group was higher than that of the TCDD group at GD13.5. The low CpG methylation level of Dnmt3a at GD13.5 which causes the up-expression of Dnmt3a may induce global hypermethylation in fetal palate tissue. The aberrant global methylation status at GD13.5 may be the cause of palate malformation in fetal mice induced by TCDD.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28336320","pmcid":null,"openalex_id":"https://openalex.org/W2588293568","authors":[],"funders":[{"funder_name":"National Natural Science Youth Foundation","grant_id":"81202167","title":null},{"funder_name":"National Key Clinical Specialist Construction Project Foundation","grant_id":"(2013)544","title":null},{"funder_name":"Yuzhong District Science and Technology planning project","grant_id":"20130121","title":null},{"funder_name":"Yuzhong District Science and Technology planning project","grant_id":"20150112","title":null}],"total_grants":4,"fwci":1.5303,"citation_percentile":0.82195441,"influential_citations":2,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":7},{"year":2020,"count":4},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S101051821730063X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S101051821730063X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jcms.2017.02.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28336320","host_type":"repository"}],"fields_of_study":["Epigenetics and DNA Methylation","Cleft Lip and Palate Research","Neonatal Respiratory Health Research","Biology","Medicine","Environmental Science","Animals","Cleft Palate","DNA Methylation","DNA Modification Methylases","Female","Gene Expression","Mice","Mice, Inbred C57BL","Palate","Polychlorinated Dibenzodioxins","Pregnancy","Real-Time Polymerase Chain Reaction"],"mesh_terms":["Polychlorinated Dibenzodioxins","Animals","Cleft Palate","Female","Mice, Inbred C57BL","Palate","Pregnancy","DNA Modification Methylases","Gene Expression","DNA Methylation","Mice","Real-Time Polymerase Chain Reaction"],"keywords":["DNA methylation","Methylation","CpG site","Epigenetics","Methyltransferase","Biology","Fetus","DNA methyltransferase","Andrology","Molecular biology","Bisulfite sequencing","Gene expression","DNA","Genetics","Gene","Pregnancy","Medicine","Cleft palate","CpG Island","Dna Methyltransferases (Dnmts)","2,3,7,8-Tetrachlrodibenzo-p-dioxin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T15:13:39.629159Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}