{"doi":"10.1016/j.jcmgh.2021.01.018","title":"STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer","abstract":"BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor microenvironment renders patients resistant to emerging immune-targeted therapies. Building from our prior work, we evaluated stimulator of interferon genes (STING) agonist activation of PDA cell interferon-α/β-receptor (IFNAR) signaling in systemic antitumor immune responses. METHODS: PDA cells were implanted subcutaneously to wild-type, IFNAR-, or CXCR3-knockout mice. Tumor growth was monitored, and immune responses were comprehensively profiled. RESULTS: mice treated with STING agonist. CONCLUSIONS: These data indicate that STING agonists promote T-cell infiltration and counteract immune suppression in locally treated and distant tumors. Tumor-intrinsic type I IFN signaling initiated systemic STING-mediated antitumor inflammation and required CXCR3 expression. STING-mediated induction of systemic immune responses provides an approach to harness the immune system to treat primary and disseminated pancreatic cancers.","journal":"Cellular and Molecular Gastroenterology and Hepatology","year":2021,"id":155457,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9624,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":659129,"name":"Nicholas S. Barnekow","orcid":null,"position":1,"is_corresponding":false},{"id":489239,"name":"Donna McAllister","orcid":"0000-0001-7332-1292","position":2,"is_corresponding":false},{"id":659130,"name":"Laura McOlash","orcid":null,"position":3,"is_corresponding":false},{"id":489767,"name":"Mahmoud Abu Eid","orcid":null,"position":4,"is_corresponding":false},{"id":366865,"name":"Matthew J. Riese","orcid":"0000-0002-2423-0017","position":5,"is_corresponding":false},{"id":658162,"name":"Vera L. Tarakanova","orcid":"0000-0002-9499-088X","position":6,"is_corresponding":false},{"id":658163,"name":"Bryon D. Johnson","orcid":"0000-0001-7416-3396","position":7,"is_corresponding":false},{"id":295006,"name":"Michael B. Dwinell","orcid":"0000-0001-5372-633X","position":8,"is_corresponding":false},{"id":658161,"name":"Emily P. Vonderhaar","orcid":"0000-0002-1158-7252","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T23:44:03.750995Z","pmid":"33548597","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}