{"doi":"10.1016/j.jcmg.2025.10.012","title":"Statin Effects on Pericoronary Adipose Tissue Density in People With HIV","abstract":"BACKGROUND: The effects of statin therapy on pericoronary adipose tissue (PCAT) and its relationship with plaque progression and outcomes in people with HIV (PWH) remain poorly understood. OBJECTIVES: The aim of this study was to evaluate PCAT density changes over time; statin effects on PCAT; and associations among PCAT changes, coronary plaque, and clinical outcomes. METHODS: In the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) mechanistic computed tomographic (CT) substudy (n = 753, mean age: 51 ± 6 years, 17% women), PCAT density was measured from noncontrast CT images at baseline and 2 years, while coronary plaque volumes (total, calcified, and noncalcified) were assessed from contrast-enhanced CT angiograms. Analyses were stratified by coronary artery disease burden (segment involvement score 0, 1-3, or ≥4) and adjusted for technical parameters, atherosclerotic cardiovascular disease risk, body mass index, inflammatory biomarkers, and statin allocation. Associations among PCAT, plaque changes, and events (all-cause mortality, major adverse cardiovascular events [MACE], and MACE or death) were evaluated. RESULTS: ; P = 0.031). Over a median of 6.3 years, 4.2% of patients died. Baseline PCAT density was independently associated with all-cause mortality (HR per +10 HU: 1.95; 95% CI: 1.03-3.69; P = 0.040), but not MACE. CONCLUSIONS: PCAT density increases over time in PWH, but pitavastatin mitigates this in those with high coronary artery disease burden. PCAT density is associated with vulnerable plaque morphology and all-cause mortality, supporting its potential as a prognostic imaging biomarker in PWH. (Randomized Trial to Prevent Vascular Events in HIV [REPRIEVE]; NCT02344290).","journal":"JACC. Cardiovascular imaging","year":2025,"id":583786,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9338,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02344290"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":653781,"name":"Ibrahim Hadžić","orcid":"0000-0002-8397-5940","position":1,"is_corresponding":false},{"id":282480,"name":"Thomas Mayrhofer","orcid":"0000-0001-6287-5185","position":2,"is_corresponding":false},{"id":322819,"name":"Júlia Karády","orcid":"0000-0002-6640-6260","position":3,"is_corresponding":false},{"id":503214,"name":"Jana Taron","orcid":"0000-0002-1388-7531","position":4,"is_corresponding":false},{"id":585883,"name":"Márton Kolossváry","orcid":"0000-0002-5570-991X","position":5,"is_corresponding":false},{"id":402710,"name":"Vineet K. Raghu","orcid":"0000-0003-3524-3945","position":6,"is_corresponding":false},{"id":759908,"name":"Sara McCallum","orcid":"0000-0002-0289-1295","position":7,"is_corresponding":false},{"id":975377,"name":"Kayla Paradis","orcid":null,"position":8,"is_corresponding":false},{"id":1015265,"name":"Marissa R Diggs","orcid":null,"position":9,"is_corresponding":false},{"id":446489,"name":"Sarah M Chu","orcid":null,"position":10,"is_corresponding":false},{"id":1044027,"name":"Amy Shirong Lu","orcid":"0000-0002-8230-9049","position":11,"is_corresponding":false},{"id":380844,"name":"Charurut Somboonwit","orcid":"0000-0001-6210-7231","position":12,"is_corresponding":false},{"id":400479,"name":"José Ignacio Bernardino","orcid":"0000-0003-3501-8529","position":13,"is_corresponding":false},{"id":575519,"name":"Michael P. Dubé","orcid":"0000-0001-6155-1023","position":14,"is_corresponding":false},{"id":442603,"name":"Craig A. Sponseller","orcid":null,"position":15,"is_corresponding":false},{"id":381595,"name":"Markella V. Zanni","orcid":"0000-0002-4711-3956","position":16,"is_corresponding":false},{"id":329844,"name":"Gerald S. Bloomfield","orcid":"0000-0002-7176-1611","position":17,"is_corresponding":false},{"id":380908,"name":"Carlos Malvestutto","orcid":"0000-0003-3156-2965","position":18,"is_corresponding":false},{"id":335272,"name":"Carl J. Fichtenbaum","orcid":"0000-0002-6778-7253","position":19,"is_corresponding":false},{"id":12096,"name":"Judith A. Aberg","orcid":"0000-0001-8162-0284","position":20,"is_corresponding":false},{"id":396976,"name":"Judith S. Currier","orcid":"0000-0003-4279-4737","position":21,"is_corresponding":false},{"id":396977,"name":"Heather J. Ribaudo","orcid":"0000-0002-0394-3990","position":22,"is_corresponding":false},{"id":282488,"name":"Pamela S. Douglas","orcid":"0000-0001-9876-4049","position":23,"is_corresponding":false},{"id":282485,"name":"Michael T. Lu","orcid":"0000-0003-4696-9610","position":24,"is_corresponding":false},{"id":12007,"name":"Steven Grinspoon","orcid":"0000-0002-6338-000X","position":25,"is_corresponding":false},{"id":282486,"name":"Borek Foldyna","orcid":"0000-0002-2466-4827","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T02:59:07.970345Z","pmid":"41324519","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}