{"doi":"10.1016/j.jcjd.2022.11.003","title":"Recent Developments in Islet Biology: A Review With Patient Perspectives","abstract":null,"journal":"Canadian Journal of Diabetes","year":2023,"id":647952,"datarank":0.3551920907223961,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.06330556836409908,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.06330556836409908,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1688349,"name":"Vriti Bhagat","orcid":"0000-0001-9423-6759","position":1,"is_corresponding":false},{"id":1688350,"name":"Ma Enrica Angela Ching","orcid":"0000-0002-8458-8440","position":2,"is_corresponding":false},{"id":1688351,"name":"Anna Di Giandomenico","orcid":null,"position":3,"is_corresponding":false},{"id":1688352,"name":"Sylvie Dostie","orcid":"0000-0003-1349-978X","position":4,"is_corresponding":false},{"id":1688353,"name":"Dana Greenberg","orcid":"0000-0002-1501-4267","position":5,"is_corresponding":false},{"id":1688354,"name":"Marley Greenberg","orcid":"0000-0001-7678-8699","position":6,"is_corresponding":false},{"id":1688355,"name":"Jiwon Hahm","orcid":"0000-0002-3698-1993","position":7,"is_corresponding":false},{"id":1688356,"name":"N. 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First, we discuss new insights into the role of glucokinase, mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase and mitochondrial function on insulin secretion from the pancreatic β cell, provided by new genetically modified mouse models and live imaging. We then discuss a new connection between lipid handling and improved insulin secretion in the context of glucotoxicity, focussing on fatty acid-binding protein 4 and fetuin-A. Advances in high-throughput \"omic\" analysis evolved to where one can generate more finely tuned genetic and molecular profiles within broad classifications of type 1 diabetes and type 2 diabetes. Next, we highlight breakthroughs in diabetes treatment using stem cell-derived β cells and innovative strategies to improve islet survival posttransplantation. Last, we update our understanding of the impact of severe acute respiratory syndrome-coronavirus-2 infection on pancreatic islet function and discuss current evidence regarding proposed links between COVID and new-onset diabetes. We address these breakthroughs in 2 settings: one for a scientific audience and the other for the public, particularly those living with or affected by diabetes. Bridging biomedical research in diabetes to the community living with or affected by diabetes, our partners living with type 1 diabetes or type 2 diabetes also provide their perspectives on these latest advances in islet biology.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36481263","pmcid":"PMC9640377","openalex_id":"https://openalex.org/W4308461274","authors":[],"funders":[{"funder_name":"Diabetes Canada","grant_id":"OG-3-21-5584-RS","title":null},{"funder_name":"Diabetes Canada","grant_id":"OG-3-21-5591-EM","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"PJT-168853","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":4,"fwci":0.8414,"citation_percentile":0.73014092,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"green","license":"CC BY NC ND","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9640377","host_type":"repository"},{"url":"https://doi.org/10.1016/j.jcjd.2022.11.003","host_type":"HYBRID"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9640377","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1499267122004336?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1499267122004336?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36481263","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9640377","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9640377?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.jcjd.2022.11.003","host_type":""}],"fields_of_study":["Pancreatic function and diabetes","Diabetes and associated disorders","Diabetes Management and Research","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["COVID-19","Animals","Biology","Diabetes Mellitus, Type 1","Diabetes Mellitus, Type 2","Humans","Insulin","Islets of Langerhans","Insulin-Secreting Cells","Mice"],"keywords":["Type 2 diabetes","Medicine","Type 1 diabetes","Diabetes mellitus","Context (archaeology)","Islet","Bioinformatics","Disease","Insulin","Biology","Endocrinology","Internal medicine","Mitochondria","Lipids","insulin secretion","Patient Engagement","Lipides","Mitochondrie","Sécrétion D’insuline","Stem Cell Encapsulation","Islet Biology","Covid","Biologie Des Îlots Pancréatiques","Cellules Souches Encapsulation","Collaboration Des Patients","COVID-19","Review","Mice","Islets of Langerhans","Diabetes Mellitus, Type 1","Diabetes Mellitus, Type 2","Insulin-Secreting Cells","Animals","Humans"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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