{"doi":"10.1016/j.jcis.2024.11.033","title":"Bioinspired black phosphorus delivers histone deacetylase inhibitor-induced synergistic therapy for lung cancer","abstract":null,"journal":"Journal of Colloid and Interface Science","year":2025,"id":637107,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":51136,"name":"Xiaoling Guan","orcid":null,"position":1,"is_corresponding":false},{"id":1654052,"name":"Songpei Li","orcid":null,"position":2,"is_corresponding":false},{"id":1654055,"name":"Xiaohua Deng","orcid":null,"position":3,"is_corresponding":false},{"id":51135,"name":"Yinshan Lin","orcid":null,"position":4,"is_corresponding":false},{"id":915376,"name":"Dan Wu","orcid":"0000-0002-2611-7317","position":5,"is_corresponding":false},{"id":1448530,"name":"Yuanyuan Wu","orcid":"0000-0002-5175-1408","position":6,"is_corresponding":false},{"id":1654058,"name":"Dazhi Zhou","orcid":null,"position":7,"is_corresponding":false},{"id":1640423,"name":"Yiwen Tao","orcid":null,"position":8,"is_corresponding":false},{"id":1654060,"name":"Mingde Fan","orcid":null,"position":9,"is_corresponding":false},{"id":51140,"name":"Lingmin Zhang","orcid":null,"position":10,"is_corresponding":false},{"id":236983,"name":"Huan Li","orcid":"0009-0002-2551-9127","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Bioinspired black phosphorus delivers histone deacetylase inhibitor-induced synergistic therapy for lung cancer","abstract":"Lung cancer remains one of the most fatal cancers worldwide, with a high incidence of metastasis and a low 5-year survival rate. Histone deacetylase inhibitors (HDACis) have shown significant potential in lung cancer treatment, but their clinical use is often hindered by poor water solubility, rapid clearance, and systemic toxicity. In this study, we developed a novel therapeutic strategy by camouflaging black phosphorus (BP) with M1 macrophage membranes (MB) and loaded HDACi suberoylanilide hydroxamic acid (SAHA) onto the camouflaged black phosphorus (MB) for targeted lung cancer therapy. The M1 membrane coating enhanced the specificity of the SAHA-loaded black phosphorus toward lung cancer cells. Black phosphorus not only served as a carrier for HDACis but also facilitated photothermal therapy (PTT) through its photothermal conversion capabilities, establishing a highly efficient therapeutic platform. MBS demonstrated strong antitumor activity with minimal systemic toxicity. This multifunctional platform, inspired by biological systems, shows great promise for delivering a wide range of HDACis and offers synergistic therapeutic potential through the combination of photothermal therapy and chemotherapy.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39571351","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"32171312","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82072047","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82170008","title":null},{"funder_name":"Second Affiliated Hospital of Guangzhou Medical University","grant_id":"202201-303","title":null},{"funder_name":"Guangzhou Municipal Science and Technology Project","grant_id":"2024A03J0891","title":null},{"funder_name":"Guangzhou Municipal Science and Technology Project","grant_id":"SL2022A03J00613","title":null},{"funder_name":"Guangzhou Municipal Science and Technology Project","grant_id":"202201011593","title":null}],"total_grants":7,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0021979724025906?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021979724025906?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":["Medicine","Materials Science","Histone Deacetylase Inhibitors","Lung Neoplasms","Humans","Phosphorus","Mice","Animals","Vorinostat","Antineoplastic Agents","Cell Survival","Cell Proliferation","Drug Screening Assays, Antitumor","Photothermal Therapy","Surface Properties","Particle Size","Drug Carriers"],"mesh_terms":["Histone Deacetylase Inhibitors","Lung Neoplasms","Humans","Phosphorus","Mice","Animals","Vorinostat","Antineoplastic Agents","Cell Survival","Cell Proliferation","Drug Screening Assays, Antitumor","Photothermal Therapy","Surface Properties","Particle Size","Drug Carriers"],"keywords":["Bioinspired nanoparticles","Black phosphorus","HDACi","Lung cancer","Photothermal therapy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:19:31.725348Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}