{"doi":"10.1016/j.jchromb.2009.01.008","title":"Lipidomic analysis of endocannabinoid metabolism in biological samples","abstract":null,"journal":"Journal of Chromatography B","year":2009,"id":644662,"datarank":2.6995950650268092,"base_score":4.6913478822291435,"endowment":4.6913478822291435,"self_citation_contribution":0.7037021823343717,"citation_network_contribution":1.9958928826924378,"self_endowment_contribution":0.7037021823343717,"citer_contribution":1.9958928826924378,"corpus_percentile":null,"corpus_rank":null,"citation_count":108,"citer_count":67,"citers_with_citation_signal":59,"citers_with_endowment":59,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":397675,"name":"Daniele Piomelli","orcid":"0000-0002-2983-774X","position":1,"is_corresponding":false},{"id":346076,"name":"Giuseppe Astarita","orcid":"0000-0001-6700-301X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lipidomic analysis of endocannabinoid metabolism in biological samples","abstract":"The endocannabinoids are signaling lipids present in many living organisms. They activate G protein-coupled cannabinoid receptors to modulate a broad range of biological processes that include emotion, cognition, inflammation and reproduction. The endocannabinoids are embedded in an interconnected network of cellular lipid pathways, the regulation of which is likely to control the strength and duration of endocannabinoid signals. Therefore, physiopathological or pharmacological perturbations of these pathways may indirectly affect endocannabinoid activity and, vice versa, endocannabinoid activity may influence lipid pathways involved in other metabolic and signaling events. Recent progress in liquid chromatography and mass spectrometry has fueled the development of targeted lipidomic approaches, which allow researchers to examine complex lipid interactions in cells and gain a broader view of the endocannabinoid system. Here, we review these new developments from the perspective of our laboratory's experience in the field.","is_dataset_classified":null,"base_score":4.6913478822291435,"endowment":4.6913478822291435,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19171504","pmcid":"PMC2723187","openalex_id":"https://openalex.org/W2067198217","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"P50 AG016573","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01DK-073955","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA012447","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA012413","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01DA-012447","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R21DA-022702","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK073955","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"RL1 AA017538","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR274-297/3504008","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P50 AG16573","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA-012413","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R21 DA022702","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"RR274-305/3505998","title":null},{"funder_name":"NIAAA NIH HHS","grant_id":"1RL1AA017538","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R21 DA022478","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA021644","title":null}],"total_grants":16,"fwci":11.9096,"citation_percentile":0.98919902,"influential_citations":0,"citation_trend":[{"year":2012,"count":23},{"year":2013,"count":6},{"year":2014,"count":4},{"year":2015,"count":11},{"year":2016,"count":12},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":5},{"year":2021,"count":6},{"year":2022,"count":6},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://escholarship.org/content/qt58h618f1/qt58h618f1.pdf","host_type":"repository"},{"url":"https://escholarship.org/content/qt58h618f1/qt58h618f1.pdf","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1570023209000208?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1570023209000208?httpAccept=text/plain","host_type":"publisher"},{"url":"https://escholarship.org/uc/item/58h618f1","host_type":"repository"},{"url":"https://doi.org/10.1016/j.jchromb.2009.01.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19171504","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2723187","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/58h618f1","host_type":"repository"}],"fields_of_study":["Cannabis and Cannabinoid Research","Forensic Toxicology and Drug Analysis","Diet, Metabolism, and Disease"],"mesh_terms":["Animals","Humans","Lipids","Computational Biology","Lipid Metabolism","Cannabinoid Receptor Modulators","Endocannabinoids"],"keywords":["Endocannabinoid system","Cannabinoid receptor","Lipid signaling","Chemistry","Lipid metabolism","Lipidomics","Cannabinoid","Monoacylglycerol lipase","Neuroscience","Anandamide","Receptor","Biochemistry","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:46:35.762103Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}