{"doi":"10.1016/j.jchf.2022.05.009","title":"Transvenous Right Greater Splanchnic Nerve Ablation in Heart Failure and Preserved Ejection Fraction","abstract":"BACKGROUND: Ablation of the right-sided greater splanchnic nerve (GSN) can reduce excessive splanchnic vasoconstriction, potentially improving the handling of volume shifts in patients with heart failure with preserved ejection fraction (HFpEF). OBJECTIVES: The purpose of this study was to assess a novel catheter procedure of right-sided GSN ablation to treat HFpEF: splanchnic ablation for volume management. METHODS: This trial included 11 HFpEF patients (8 women, age 70 ± 8 years) with New York Heart Association functional class II or III symptoms, ejection fraction ≥50%, and elevated pulmonary capillary wedge pressure at rest or with exercise. After splanchnic ablation for volume management, follow-up at 1, 3, 6, and 12 months included 6-minute walk test, Kansas City Cardiomyopathy Questionnaire (KCCQ), and echocardiography. RESULTS: There were no device-related adverse cardiac events or clinical sequelae following right GSN ablation through 12 months. Patients experienced clinical improvements by 1 month that were sustained through 12 months. KCCQ score improved from baseline median 48 (IQR: 35-52) to 65 (IQR: 58-77) at 1 month and 80 (IQR: 77-88) at 12 months (P < 0.05). The 6-minute walk test distance increased from baseline 292 ± 82 m to 341 ± 88 m at 1 month and 359 ± 75 m at 12 months (P < 0.05). The NT-proBNP decreased from a baseline mean of 1,292 ± 1,186 pg/mL to 1,202 ± 797 pg/mL (P = 0.585) at 1 month, to 472 ± 226 pg/mL (P = 0.028) at 6 months, and to 379 ± 165 pg/mL (P = 0.039) at 12 months. CONCLUSIONS: In this open-label, single-arm feasibility study, right-sided GSN ablation was safe and improved mostly subjective clinical metrics in patients with HFpEF over 12 months. (Endovascular GSN Ablation in Subjects With HFpEF; NCT04287946).","journal":"JACC Heart Failure","year":2022,"id":248169,"datarank":0.9127895298365784,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.3929291444166193,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.3929291444166193,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":22,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04287946"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":144830,"name":"Teona Zirakashvili","orcid":null,"position":1,"is_corresponding":false},{"id":887557,"name":"Nikoloz Shaburishvili","orcid":null,"position":2,"is_corresponding":false},{"id":886913,"name":"Giorgi Shaishmelashvili","orcid":"0009-0005-1253-8857","position":3,"is_corresponding":false},{"id":887558,"name":"Horst Sievert","orcid":null,"position":4,"is_corresponding":false},{"id":887559,"name":"Kolja Sievert","orcid":null,"position":5,"is_corresponding":false},{"id":610800,"name":"Vivek Y. Reddy","orcid":"0000-0002-5638-4993","position":6,"is_corresponding":false},{"id":887560,"name":"Zoar J. Engelman","orcid":null,"position":7,"is_corresponding":false},{"id":230591,"name":"Daniel Burkhoff","orcid":"0000-0003-3995-2466","position":8,"is_corresponding":false},{"id":887561,"name":"Tamaz Shaburishvili","orcid":null,"position":9,"is_corresponding":false},{"id":235994,"name":"Sanjiv J. Shah","orcid":"0000-0002-5655-8201","position":10,"is_corresponding":false},{"id":274214,"name":"Marat Fudim","orcid":"0000-0002-8671-7007","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T00:24:09.893688Z","pmid":"36175060","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}