{"doi":"10.1016/j.jcf.2023.05.013","title":"Automatic bronchus and artery analysis on chest computed tomography to evaluate the effect of inhaled hypertonic saline in children aged 3-6 years with cystic fibrosis in a randomized clinical trial","abstract":"BackgroundSHIP-CT showed that 48-week treatment with inhaled 7% hypertonic saline (HS) reduced airway abnormalities on chest CT using the manual PRAGMA-CF method relative to isotonic saline (IS) in children aged 3-6 years with cystic fibrosis (CF). An algorithm was developed and validated to automatically measure bronchus and artery (BA) dimensions of BA-pairs on chest CT. Aim of the study was to assess the effect of HS on bronchial wall thickening and bronchial widening using the BA-analysis.MethodsThe BA-analysis (LungQ, version 2.1.0.1, Thirona, Netherlands) automatically segments the bronchial tree and identifies the segmental bronchi (G0) and distal generations (G1-G10). Dimensions of each BA-pair are measured: diameters of bronchial outer wall (Bout), bronchial inner wall (Bin), bronchial wall thickness (Bwt), and artery (A). BA-ratios are computed: Bout/A and Bin/A to detect bronchial widening and Bwt/A and Bwa/Boa (=bronchial wall area/bronchial outer area) to detect bronchial wall thickening.Results113 baseline and 102 48-week scans of 115 SHIP-CT participants were analysed. LungQ measured at baseline and 48-weeks respectively 6,073 and 7,407 BA-pairs in the IS-group and 6,363 and 6,840 BA-pairs in the HS-group. At 48 weeks, Bwt/A (mean difference 0.011; 95%CI, 0.0017 to 0.020) and Bwa/Boa (mean difference 0.030; 95% 0.009 to 0.052) was significantly higher (worse) in the IS-group compared to the HS-group representing more severe bronchial wall thickening in the IS-group (p=0.025 and p=0.019 respectively). Bwt/A and Bwa/Boa decreased and Bin/A remained stable from baseline to 48 weeks in the HS while it declined in the IS-group (all p<0.001). There was no difference in progression of Bout/A between two treatment groups.ConclusionThe automatic BA-analysis showed a positive impact of inhaled HS on bronchial lumen and wall thickness, but no treatment effect on progression of bronchial widening over 48 weeks.","journal":"Journal of Cystic Fibrosis","year":2023,"id":333878,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9629,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1061703,"name":"Qianting Lv","orcid":"0000-0003-1113-9481","position":1,"is_corresponding":false},{"id":429681,"name":"Eleni‐Rosalina Andrinopoulou","orcid":"0000-0002-5372-4163","position":2,"is_corresponding":false},{"id":1061704,"name":"Leticia Gallardo-Estrella","orcid":"0000-0003-3446-2687","position":3,"is_corresponding":false},{"id":578803,"name":"Jean‐Paul Charbonnier","orcid":null,"position":4,"is_corresponding":false},{"id":542945,"name":"Daan Caudri","orcid":"0000-0002-8191-8598","position":5,"is_corresponding":false},{"id":442437,"name":"Stephanie D. Davis","orcid":"0000-0002-9390-0651","position":6,"is_corresponding":false},{"id":393553,"name":"Margaret Rosenfeld","orcid":"0000-0002-8105-614X","position":7,"is_corresponding":false},{"id":337408,"name":"Félix Ratjen","orcid":"0000-0003-4057-6592","position":8,"is_corresponding":false},{"id":447122,"name":"Richard A. Kronmal","orcid":"0000-0002-9897-7076","position":9,"is_corresponding":false},{"id":811141,"name":"Karen Hinckley Stukovsky","orcid":"0000-0003-4781-2471","position":10,"is_corresponding":false},{"id":608884,"name":"Stephen M. Stick","orcid":"0000-0002-5386-8482","position":11,"is_corresponding":false},{"id":610120,"name":"Harm A.W.M. Tiddens","orcid":"0000-0001-5628-6667","position":12,"is_corresponding":false},{"id":1061702,"name":"Yuxin Chen","orcid":"0000-0003-2549-0838","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:09:44.297718Z","pmid":"37246053","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}