{"doi":"10.1016/j.jcf.2020.11.016","title":"Clinical evaluation of an evidence-based method based on food characteristics to adjust pancreatic enzyme supplements dose in cystic fibrosis","abstract":null,"journal":"Journal of Cystic Fibrosis","year":2021,"id":672821,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1757951,"name":"Mieke Boon","orcid":null,"position":1,"is_corresponding":false},{"id":1377179,"name":"Carla Colombo","orcid":"0000-0003-0716-481X","position":2,"is_corresponding":false},{"id":1757952,"name":"Barbara de Koning","orcid":null,"position":3,"is_corresponding":false},{"id":1757953,"name":"Inês Asseiceira","orcid":null,"position":4,"is_corresponding":false},{"id":1757954,"name":"Maria Garriga","orcid":null,"position":5,"is_corresponding":false},{"id":1757956,"name":"Maria Roca","orcid":"0000-0001-8157-2446","position":6,"is_corresponding":false},{"id":1757958,"name":"Ine Claes","orcid":null,"position":7,"is_corresponding":false},{"id":1757960,"name":"Anna Bulfamante","orcid":null,"position":8,"is_corresponding":false},{"id":1757962,"name":"Sylvia Walet","orcid":null,"position":9,"is_corresponding":false},{"id":1710582,"name":"Luisa Pereira","orcid":"0000-0001-7235-2484","position":10,"is_corresponding":false},{"id":1757964,"name":"Mar Ruperto","orcid":null,"position":11,"is_corresponding":false},{"id":1757965,"name":"Etna Masip","orcid":null,"position":12,"is_corresponding":false},{"id":1757966,"name":"Andrea Asensio-Grau","orcid":null,"position":13,"is_corresponding":false},{"id":1757967,"name":"Arianna Giana","orcid":null,"position":14,"is_corresponding":false},{"id":1757968,"name":"Philine Affourtit","orcid":null,"position":15,"is_corresponding":false},{"id":1757969,"name":"Ana Heredia","orcid":null,"position":16,"is_corresponding":false},{"id":1757970,"name":"Saioa Vicente","orcid":null,"position":17,"is_corresponding":false},{"id":1757971,"name":"Ana Andrés","orcid":null,"position":18,"is_corresponding":false},{"id":1757972,"name":"Kris de Boeck","orcid":null,"position":19,"is_corresponding":false},{"id":1258260,"name":"Jessie M. Hulst","orcid":"0000-0002-4899-7343","position":20,"is_corresponding":false},{"id":1757973,"name":"Carmen Ribes-Koninckx","orcid":null,"position":21,"is_corresponding":false},{"id":1757950,"name":"Joaquim Calvo-Lerma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical evaluation of an evidence-based method based on food characteristics to adjust pancreatic enzyme supplements dose in cystic fibrosis","abstract":"<h4>Background</h4>Patients with cystic fibrosis (CF) and pancreatic insufficiency need pancreatic enzyme replacement therapy (PERT) for dietary lipids digestion. There is limited evidence for recommending the adequate PERT dose for every meal, and controlling steatorrhea remains a challenge. This study aimed to evaluate a new PERT dosing method supported by a self-management mobile-app.<h4>Methods</h4>Children with CF recruited from 6 European centres were instructed to use the app, including an algorithm for optimal PERT dosing based on in vitro digestion studies for every type of food. At baseline, a 24h self-selected diet was registered in the app, and usual PERT doses were taken by the patient. After 1 month, the same diet was followed, but PERT doses were indicated by the app. Change in faecal fat and coefficient of fat absorption (CFA) were determined.<h4>Results</h4>58 patients (median age 8.1 years) participated. Baseline fat absorption was high: median CFA 96.9%, median 2.4g faecal fat). After intervention CFA did not significantly change, but range of PERT doses was reduced: interquartile ranges narrowing from 1447-3070 at baseline to 1783-2495 LU/g fat when using the app. Patients with a low baseline fat absorption (CFA<90%, n=12) experienced significant improvement in CFA after adhering to the recommended PERT dose (from 86.3 to 94.0%, p=0.031).<h4>Conclusion</h4>the use of a novel evidence-based PERT dosing method, based on in vitro fat digestion studies incorporating food characteristics, was effective in increasing CFA in patients with poor baseline fat absorption and could safely be implemented in clinical practice.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33279468","pmcid":null,"openalex_id":"https://openalex.org/W3106733940","authors":[],"funders":[{"funder_name":"Horizon 2020 Framework Programme","grant_id":"643806","title":"Innovative approach for self-management and social welfare of Cystic Fibrosis patients in Europe: development, validation and implementation of a telematics tool."},{"funder_name":"Horizon 2020 Framework Programme","grant_id":"PHC-26-2014","title":null},{"funder_name":"European Commission","grant_id":"","title":null},{"funder_name":"Horizon 2020","grant_id":"","title":null}],"total_grants":4,"fwci":1.426,"citation_percentile":0.85274455,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://pure.eur.nl/en/publications/f25ae6a3-95fa-4b2a-a1a9-dd4e35858d4e","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/f25ae6a3-95fa-4b2a-a1a9-dd4e35858d4e","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1569199320309267?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1569199320309267?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jcf.2020.11.016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33279468","host_type":"repository"},{"url":"https://lirias.kuleuven.be/bitstream/20.500.12942/693502/2/JCF_Clinical%20Evaluation%20of%20an%20evidence-based%20method%20on%20food%20characteristics.pdf","host_type":"repository"},{"url":"http://www.scopus.com/inward/record.url?scp=85097149532&partnerID=8YFLogxK","host_type":"repository"},{"url":"http://hdl.handle.net/10251/181760","host_type":"repository"},{"url":"https://riunet.upv.es/handle/10251/181760","host_type":""},{"url":"https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13535","host_type":""},{"url":"https://dx.doi.org/10.1016/j.jcf.2020.11.016","host_type":""},{"url":"https://hdl.handle.net/2434/799973","host_type":""}],"fields_of_study":["Cystic Fibrosis Research Advances","Pancreatitis Pathology and Treatment","Child Nutrition and Feeding Issues","0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Child","Cystic Fibrosis","Diet","Europe","Female","Humans","Male","Pancreas","Evidence-Based Medicine","Enzyme Replacement Therapy","Mobile Applications"],"keywords":["Medicine","Cystic fibrosis","Interquartile range","Dosing","Steatorrhea","Meal","Exocrine pancreatic insufficiency","Gastroenterology","Internal medicine","Digestion (alchemy)","Digestion","In vitro digestion","Paediatrics","Pancreatic Enzyme Replacement Therapy","Pancreatic Insufficiency","Coefficient Of Fat Absorption","Male","Coefficient of fat absorption, Cystic fibrosis, Digestion, In vitro digestion, Paediatrics, Pancreatic enzyme replacement therapy, Pancreatic insufficiency","TECNOLOGIA DE ALIMENTOS","Humans","Enzyme Replacement Therapy","Child","Pancreas","Evidence-Based Medicine","Mobile Applications","Diet","Europe","Coefficient of fat absorption; Cystic fibrosis; Digestion; In vitro digestion; Paediatrics; Pancreatic enzyme replacement therapy; Pancreatic insufficiency","EMC MM-04-54-07","DigestionPaediatrics","Female"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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