{"doi":"10.1016/j.jcct.2025.08.003","title":"Three-dimensional left atrial strain from retrospective gated computed tomography: Comparison with speckle-tracking echocardiography in patients with aortic stenosis","abstract":"Background: Three-dimensional (3D) left atrial (LA) deformation assessment beyond the two-dimensional (2D) apical views circumvents atrial foreshortening and can be quantified from four-dimensional (4D) retrospective gated computed tomography (CT) using novel feature tracking methods.However, the consistency between CTderived 3D and echocardiographic 2D peak left atrial longitudinal strain (PALS) has not been reported.We aimed to compare CT-derived 3D and echocardiographic 2D PALS in patients undergoing transcatheter aortic valve implantation (TAVI).Methods: Eighty patients (81.8 5.8 years, 30 % female) who underwent CT and transthoracic echocardiography (TTE) before TAVI were included.CT images were reconstructed at 5 % increments over the R-R interval.4D CTderived deformation was evaluated using novel feature tracking, from which 2D and 3D PALS CT were measured and compared with 2D PALS TTE .Results: 2D PALS TTE and 2D PALS CT measurements were strongly correlated (Pearson coefficient = 0.84) and comparable (mean bias = -0.8;95 % confidence interval, CI: -1.9 to 0.3), whereas 2D PALS TTE exhibited systematic overestimation compared with 3D PALS CT (mean bias = -3.6;95 % CI: -4.7 to -2.5; P < 0.001).3D PALS CT and 2D PALS TTE exhibited comparable correlations with exercise capacity and quality of life scores and prediction of elevated brain natriuretic peptide (area under the curve, AUC: 0.84, 0.79, respectively) and diastolic filling pressures (AUC: 0.65, 0.69, respectively).Conclusion: 2D PALS CT and 2D PALS TTE showed good agreement, whereas 2D PALS TTE was systemically larger than 3D PALS CT which may be attributed to atrial foreshortening.3D PALS CT circumvents limitations of 2D echocardiography and may offer adjunctive evaluation of atrial reservoir function in patients with valvular heart disease.","journal":"Journal of cardiovascular computed tomography","year":2025,"id":573109,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1479954,"name":"Vitaliy Androshchuk","orcid":"0000-0002-1464-3109","position":1,"is_corresponding":false},{"id":1479955,"name":"Edouard Long","orcid":"0009-0002-1008-7966","position":2,"is_corresponding":false},{"id":893081,"name":"Tiffany M G Baptiste","orcid":"0000-0003-3157-3568","position":3,"is_corresponding":false},{"id":638057,"name":"Marina Strocchi","orcid":"0000-0003-1312-251X","position":4,"is_corresponding":false},{"id":991705,"name":"José Alonso Solís-Lemus","orcid":"0000-0002-2596-7811","position":5,"is_corresponding":false},{"id":776094,"name":"Angela Lee","orcid":"0000-0003-2385-6875","position":6,"is_corresponding":false},{"id":360875,"name":"Caroline H. Roney","orcid":"0000-0001-6809-0928","position":7,"is_corresponding":false},{"id":541159,"name":"Ronak Rajani","orcid":"0000-0002-8816-6296","position":8,"is_corresponding":false},{"id":541158,"name":"Tiffany Patterson","orcid":"0000-0001-7619-9122","position":9,"is_corresponding":false},{"id":541164,"name":"Simon Redwood","orcid":"0000-0002-1937-063X","position":10,"is_corresponding":false},{"id":328101,"name":"Steven Niederer","orcid":"0000-0002-4612-6982","position":11,"is_corresponding":false},{"id":734675,"name":"Charles Sillett","orcid":"0000-0003-2930-7818","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T02:57:32.445190Z","pmid":"40846525","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}