{"doi":"10.1016/j.jcct.2024.04.005","title":"AI-enabled left atrial volumetry in coronary artery calcium scans (AI-CACTM) predicts atrial fibrillation as early as one year, improves CHARGE-AF, and outperforms NT-proBNP: The multi-ethnic study of atherosclerosis","abstract":"BACKGROUND: Coronary artery calcium (CAC) scans contain actionable information beyond CAC scores that is not currently reported. METHODS: ) to 5535 asymptomatic individuals (52.2% women, ages 45-84) that were previously obtained for CAC scoring in the baseline examination (2000-2002) of the Multi-Ethnic Study of Atherosclerosis (MESA). AI-CAC took on average 21 ​s per CAC scan. We used the 5-year outcomes data for incident atrial fibrillation (AF) and assessed discrimination using the time-dependent area under the curve (AUC) of AI-CAC LA volume with known predictors of AF, the CHARGE-AF Risk Score and NT-proBNP. The mean follow-up time to an AF event was 2.9 ​± ​1.4 years. RESULTS: At 1,2,3,4, and 5 years follow-up 36, 77, 123, 182, and 236 cases of AF were identified, respectively. The AUC for AI-CAC LA volume was significantly higher than CHARGE-AF for Years 1, 2, and 3 (0.83 vs. 0.74, 0.84 vs. 0.80, and 0.81 vs. 0.78, respectively, all p ​< ​0.05), but similar for Years 4 and 5, and significantly higher than NT-proBNP at Years 1-5 (all p ​< ​0.01), but not for combined CHARGE-AF and NT-proBNP at any year. AI-CAC LA significantly improved the continuous Net Reclassification Index for prediction of AF over years 1-5 when added to CHARGE-AF Risk Score (0.60, 0.28, 0.32, 0.19, 0.24), and NT-proBNP (0.68, 0.44, 0.42, 0.30, 0.37) (all p ​< ​0.01). CONCLUSION: AI-CAC LA volume enabled prediction of AF as early as one year and significantly improved on risk classification of CHARGE-AF Risk Score and NT-proBNP.","journal":"Journal of cardiovascular computed tomography","year":2024,"id":425970,"datarank":0.48243998077916156,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.040774133904195424,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.040774133904195424,"corpus_percentile":60.431654676258994,"corpus_rank":5116,"citation_count":18,"citer_count":5,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5115,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":371560,"name":"David F. Yankelevitz","orcid":"0000-0001-7364-4294","position":1,"is_corresponding":false},{"id":443588,"name":"Anthony P. Reeves","orcid":"0000-0002-1451-3080","position":2,"is_corresponding":false},{"id":24934,"name":"Matthew J. Budoff","orcid":"0000-0002-9616-1946","position":3,"is_corresponding":false},{"id":381244,"name":"Dong Li","orcid":"0000-0002-4347-7015","position":4,"is_corresponding":false},{"id":1219497,"name":"Kyle Atlas","orcid":"0000-0003-3061-3855","position":5,"is_corresponding":false},{"id":1211957,"name":"Chenyu Zhang","orcid":"0000-0002-9799-8772","position":6,"is_corresponding":false},{"id":1212652,"name":"Thomas Atlas","orcid":null,"position":7,"is_corresponding":false},{"id":390500,"name":"Seth T. Lirette","orcid":"0000-0003-2603-6071","position":8,"is_corresponding":false},{"id":1165981,"name":"Jakob Wasserthal","orcid":"0000-0002-9921-5698","position":9,"is_corresponding":false},{"id":444501,"name":"Sion Roy","orcid":null,"position":10,"is_corresponding":false},{"id":371559,"name":"Claudia I. Henschke","orcid":"0000-0002-6085-5305","position":11,"is_corresponding":false},{"id":259512,"name":"Nathan D. Wong","orcid":"0000-0003-1102-7324","position":12,"is_corresponding":false},{"id":278980,"name":"Christopher R. deFilippi","orcid":"0000-0002-0660-4943","position":13,"is_corresponding":false},{"id":24969,"name":"Susan R. Heckbert","orcid":"0000-0002-7100-512X","position":14,"is_corresponding":false},{"id":328232,"name":"Philip Greenland","orcid":"0000-0002-6327-2439","position":15,"is_corresponding":false},{"id":1211956,"name":"Morteza Naghavi","orcid":"0000-0001-8112-175X","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:58:32.160975Z","pmid":"38653606","pmcid":"PMC11216863","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}