{"doi":"10.1016/j.jcct.2014.11.006","title":"Quantification of coronary artery calcium in nongated CT to predict cardiovascular events in male lung cancer screening participants: Results of the NELSON study","abstract":null,"journal":"Journal of Cardiovascular Computed Tomography","year":2015,"id":633929,"datarank":0.6496100010429497,"base_score":4.330733340286331,"endowment":4.330733340286331,"self_citation_contribution":0.6496100010429497,"citation_network_contribution":0.0,"self_endowment_contribution":0.6496100010429497,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":75,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":361117,"name":"Ivana Išgum","orcid":"0000-0003-1869-5034","position":1,"is_corresponding":false},{"id":528772,"name":"Martin J. Willemink","orcid":"0000-0002-6991-6557","position":2,"is_corresponding":false},{"id":1582898,"name":"Yolanda van der Graaf","orcid":null,"position":3,"is_corresponding":false},{"id":305675,"name":"Harry J. de Koning","orcid":"0000-0003-4682-3646","position":4,"is_corresponding":false},{"id":636862,"name":"Rozemarijn Vliegenthart","orcid":"0000-0002-7262-3376","position":5,"is_corresponding":false},{"id":1630199,"name":"Matthijs Oudkerk","orcid":null,"position":6,"is_corresponding":false},{"id":528776,"name":"Tim Leiner","orcid":"0000-0003-1885-5499","position":7,"is_corresponding":false},{"id":21747,"name":"Pim A. de Jong","orcid":"0000-0003-4840-6854","position":8,"is_corresponding":false},{"id":1643828,"name":"Richard A.P. Takx","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Quantification of coronary artery calcium in nongated CT to predict cardiovascular events in male lung cancer screening participants: Results of the NELSON study","abstract":"<h4>Objective</h4>To evaluate the incremental prognostic value of the number and maximum volume of coronary artery calcifications over modified Agatston score strata, age, pack-years, and smoking status for predicting cardiovascular events.<h4>Methods</h4>A total of 3559 male current and former smokers received a CT examination for lung cancer screening. Smoking characteristics, patient demographics, and physician-diagnosed cardiovascular events were collected. Images were acquired without electrocardiography gating on 16-slice CT scanners. The association between the presence of both fatal and nonfatal cardiovascular events and the predictors was quantified using Cox proportional hazard analysis.<h4>Results</h4>Median follow-up period was 2.9 years. Incident cardiovascular events occurred in 186 participants. Adjusted hazard ratios for modified Agatston score strata of 1 to 10, 11 to 100, 101 to 400, and >400 were 3.39 (95% confidence interval [CI], 1.20-9.59), 6.52 (95% CI, 2.73-15.60), 6.58 (95% CI, 2.75-15.78), and 12.58 (95% CI, 5.42-29.16), respectively. Moreover, comparing the models with and without modified Agatston score strata to the model with age, pack-years, and smoking status yielded a significantly better net reclassification improvement (NRI; 27.3%; P < .0001). Adding the number of calcifications to the model with age, pack-years, smoking status, and modified Agatston score strata resulted in a slightly better NRI (1.68%; P = .0490) with a hazard ratio of 1.13 (95% CI, 1.05-1.21) per 10 calcifications. The incremental prognostic information contained in the volume of the largest calcification was not statistically significant (NRI, 0.14%; P = .3458).<h4>Conclusion</h4>Cardiovascular event rate increased with higher numbers of calcified lesions. The number but not maximum volume of calcifications has independent, although minimal, prognostic value over age, pack-years, smoking status, and modified Agatston score strata in our population.","is_dataset_classified":null,"base_score":4.330733340286331,"endowment":4.330733340286331,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25533223","pmcid":null,"openalex_id":"https://openalex.org/W1991337537","authors":[],"funders":[],"total_grants":0,"fwci":2.6413,"citation_percentile":0.88572007,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":5},{"year":2017,"count":5},{"year":2018,"count":9},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":10},{"year":2022,"count":12},{"year":2023,"count":8},{"year":2024,"count":7},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1934592514003062?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1934592514003062?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.jcct.2014.11.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25533223","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/b72325ae-4b48-4956-b6bd-a13c51fc4d58","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/1d45e11e-fcb8-44ad-a23a-3cb6c9e0672f","host_type":"repository"},{"url":"https://research.rug.nl/en/publications/b0b11a08-0b1b-4ada-b00f-9bf02f219fcb","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/quantification-of-coronary-artery-calcium-in-nongated-ct-to-predict-cardiovascular-events-in-male-lung-cancer-screening-participants-results-of-the-nelson-study(380ee173-872f-44bb-9f14-36ad910ceb2d).html","host_type":"repository"},{"url":"http://hdl.handle.net/1765/90338","host_type":"repository"},{"url":"https://hdl.handle.net/11370/b0b11a08-0b1b-4ada-b00f-9bf02f219fcb","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/331956","host_type":"repository"},{"url":"http://dspace.library.uu.nl/handle/1874/331956","host_type":"repository"}],"fields_of_study":["Cardiac Imaging and Diagnostics","Lung Cancer Diagnosis and Treatment","Cardiovascular Disease and Adiposity"],"mesh_terms":["Artificial Intelligence","Belgium","Calcinosis","Coronary Artery Disease","Humans","Lung Neoplasms","Male","Middle Aged","Netherlands","Radiographic Image Interpretation, Computer-Assisted","Sensitivity and Specificity","Smoking","Tomography, X-Ray Computed","Reproducibility of Results","Comorbidity","Causality","Incidence","Survival Rate","Coronary Angiography","Age Distribution","Risk Assessment","Early Detection of Cancer"],"keywords":["Medicine","Agatston score","Hazard ratio","Coronary artery calcium","Lung cancer screening","Confidence interval","Lung cancer","Internal medicine","Cardiology","Proportional hazards model","Coronary Calcium Score","Coronary artery disease","computed tomography","Coronary Artery Calcification","cardiovascular event"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:52:36.880053Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}